2. Gene
  3. Myc - myelocytomatosis oncogene Gene

Myc - myelocytomatosis oncogene Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Myc2; Nird; Niard; bHLHe39

Gene ID: 17869 | Gene type: protein coding

About Myc

Chromosome 15: 61,857,240-61,862,223 forward strand.GRCm39:CM001008.3

This gene has 7 transcripts (splice variants), 217 orthologues, 4 paralogues and is associated with 81 phenotypes. Broad expression in ovary adult (RPKM 36.6), thymus adult (RPKM 28.3) and 22 other tissues.

Summary

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, Apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Myc Products(4)

mRNA Protein Name
NM_001177352.1 NP_001170823.1 myc proto-oncogene protein isoform b
NM_010849.4 NP_034979.3 myc proto-oncogene protein isoform a
NM_001177354.1 NP_001170825.1 myc proto-oncogene protein isoform b
NM_001177353.1 NP_001170824.1 myc proto-oncogene protein isoform c

Myc Protein Structure

Myc_N

Myc_N: pfam01056 (1 - 344)

bHLHzip_c-Myc

bHLHzip_c-Myc: cd11458 (350 - 433)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 439 a.a.
Protein Preferred Names Protein Names

myc proto-oncogene protein

c-myc proto-oncogene

transcription factor p64

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17381A Idarubicin / Unkown
Clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-111784 Inobrodib Inhibitor 99.53% Phase 2
HY-13241 Ralimetinib dimesylate 99.91% Phase 2
HY-153356 MRT-2359 Inducer 99.98% Phase 2
HY-109050 Alobresib Inhibitor 98.04% Phase 2
HY-13241A Ralimetinib Inhibitor / Phase 2
HY-16291 APTO-253 98.81% Phase 1
HY-136938 NEO2734 Inhibitor 99.79% Phase 1
HY-145898 WBC100 Inhibitor ≥95.0% Phase 1
Pre-clinical Phase
Bioactive Molecules (133)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12702 10058-F4 Inhibitor 99.77% Unkown
HY-80013 THZ1 Inhibitor 99.84% Unkown
HY-107738 Guggulsterone 99.95% Unkown
HY-19735 KJ Pyr 9 Inhibitor 99.62% Unkown
HY-134582 dCBP-1 Inhibitor 99.44% Unkown
HY-112929 DT-061 Activator 99.95% Unkown
HY-139361 Sulfopin Inhibitor 99.69% Unkown
HY-134761 EN4 Inhibitor 97.05% Unkown
HY-139330 MGH-CP1 Inducer 99.21% Unkown
HY-124675 MYCMI-6 98.14% Unkown
HY-129600 MYCi361 Inhibitor 99.85% Unkown
HY-123954 Casein Kinase inhibitor A51 98.58% Unkown
HY-100669 Mycro 3 Inhibitor 99.21% Unkown
HY-100996 10074-G5 Inhibitor 98.52% Unkown
HY-126477 NNK 99.98% Unkown
HY-122683 sAJM589 Inhibitor 99.65% Unkown
HY-114208A BI-9321 trihydrochloride Antagonist 98.40% Unkown
HY-80013A THZ1 Hydrochloride Inhibitor 98.78% Unkown
HY-124447 BTYNB Inhibitor ≥98.0% Unkown
HY-12703 KSI-3716 Inhibitor 99.76% Unkown
HY-112296 T025 98.84% Unkown
HY-N2068 Didymin Inducer 99.96% Unkown
HY-12863 Pelabresib Inhibitor 99.95% Unkown
HY-133121 WDR5-IN-1 98.71% Unkown
HY-103038 ML327 Inhibitor 98.06% Unkown
HY-19759 SRT 2183 98.17% Unkown
HY-N0704 Agrimol B 99.75% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.97% Unkown
HY-145669 DIF-3 98.07% Unkown
HY-129937A GNE-987 Inhibitor 99.91% Unkown
HY-120028 GNE-207 Inhibitor 97.02% Unkown
HY-114189 GW284543 Inhibitor 99.99% Unkown
HY-N2534 Karanjin 99.75% Unkown
HY-135691 hnRNPK-IN-1 ≥97.0% Unkown
HY-N6747 Stauprimide Inhibitor 99.45% Unkown
HY-112316 BAY1238097 Inhibitor 99.02% Unkown
HY-144878 VPC-70619 Inhibitor ≥99.0% Unkown
HY-13250 Silvestrol aglycone Inhibitor 99.70% Unkown
HY-112799 DK419 Inhibitor 99.88% Unkown
HY-123955 Casein Kinase inhibitor A86 98.47% Unkown
HY-153713 MYC-RIBOTAC 98.05% Unkown
HY-111411 IZCZ-3 Inhibitor 98.13% Unkown
HY-124811 IRES-C11 Inhibitor 99.03% Unkown
HY-134975 NY2267 Inhibitor 99.34% Unkown
HY-133131 PROTAC BRD4 Degrader-1 Inhibitor 99.12% Unkown
HY-148836 c-Myc inhibitor 6 Inhibitor 98.04% Unkown
HY-N8146 Bruceantinol Inhibitor 98.89% Unkown
HY-112929B (1S,2S,3R)-DT-061 99.73% Unkown
HY-148450 eIF4A3-IN-16 Inhibitor 98.37% Unkown
HY-149209 LL-K8-22 99.76% Unkown
HY-121418 Lusianthridin Inhibitor ≥98.0% Unkown
HY-124129 10074-A4 Inhibitor 98.03% Unkown
HY-134333 ICCB280 Activator 99.43% Unkown
HY-147973 IZTZ-1 / Unkown
HY-148444 eIF4A3-IN-10 Inhibitor 97.87% Unkown
HY-148452 eIF4A3-IN-18 Inhibitor 99.58% Unkown
HY-112316A (R)-BAY1238097 99.07% Unkown
HY-119271 CMLD010509 / Unkown
HY-101280 LB-60-OF61 Inhibitor 99.25% Unkown
HY-111522 RK-9123016 Inhibitor 99.02% Unkown
HY-125236 BET-IN-19 Inhibitor 99.41% Unkown
HY-147651 β-catenin-IN-4 Inhibitor 99.84% Unkown
HY-148443 eIF4A3-IN-9 Inhibitor 99.71% Unkown
HY-148445 eIF4A3-IN-11 Inhibitor 99.24% Unkown
HY-148446 eIF4A3-IN-12 Inhibitor 99.70% Unkown
HY-148447 eIF4A3-IN-13 Inhibitor 99.92% Unkown
HY-148448 eIF4A3-IN-14 Inhibitor 99.81% Unkown
HY-148449 eIF4A3-IN-15 Inhibitor / Unkown
HY-148451 eIF4A3-IN-17 Inhibitor 99.56% Unkown
HY-153728 WM-586 Inhibitor / Unkown
HY-162318 MYC degrader 1 Degrader / Unkown
HY-162318A MYC degrader 1 TFA Degrader / Unkown
HY-N10790 RA-V 99.58% Unkown
HY-N12487 TRRAP-IN-1 / Unkown
HY-100653 AZD5153 / Unkown
HY-129937 (S)-GNE-987 Inhibitor / Unkown
HY-101280A LB-60-OF61 hydrochloride Inhibitor / Unkown
HY-104072 BRD4-IN-3 Inhibitor / Unkown
HY-114189A GW284543 hydrochloride Inhibitor / Unkown
HY-114208 BI-9321 Antagonist / Unkown
HY-115832 Ap44mSe / Unkown
HY-125636 Mycro1 / Unkown
HY-125978 JY-3-094 Inhibitor / Unkown
HY-126979 Mycro2 / Unkown
HY-128761 CBP/p300-IN-2 Inhibitor / Unkown
HY-131203 PROTAC BRD4 Degrader-6 / Unkown
HY-136794 SB-284851-BT Inhibitor / Unkown
HY-139885 c-Myc inhibitor 4 Inhibitor / Unkown
HY-141666 MYC-IN-2 Inhibitor / Unkown
HY-143235 BRD4 Inhibitor-15 / Unkown
HY-145843 c-Myc inhibitor 5 Inhibitor / Unkown
HY-146445 P300 bromodomain-IN-1 Inhibitor / Unkown
HY-147261 B026 Inhibitor / Unkown
HY-147291 VPC-70063 / Unkown
HY-148837 c-Myc inhibitor 7 / Unkown
HY-148838 c-Myc inhibitor 8 Inhibitor / Unkown
HY-148839 c-Myc inhibitor 9 Inhibitor / Unkown
HY-149228 USP28-IN-2 Inhibitor / Unkown
HY-149229 USP28-IN-3 Inhibitor / Unkown
HY-149230 USP28-IN-4 Inhibitor / Unkown
HY-149495 CP-07 Degrader / Unkown
HY-149513 EP12 / Unkown
HY-149735 BET-IN-20 / Unkown
HY-149873 Anticancer agent 126 Inhibitor / Unkown
HY-150259 MDEG-541 Degrader / Unkown
HY-150683 NC-III-49-1 Inhibitor / Unkown
HY-150684 GXH-II-052 Inhibitor / Unkown
HY-151471 Anticancer agent 84 Inhibitor / Unkown
HY-151884 FUBP1-IN-2 Inhibitor / Unkown
HY-152471 Eleven-Nineteen-Leukemia Protein IN-3 Inhibitor / Unkown
HY-153996 CT1113 Inhibitor / Unkown
HY-154839 c-Myc inhibitor 10 Inhibitor / Unkown
HY-154847 WM-662 Inhibitor / Unkown
HY-155153 CDK9-IN-24 / Unkown
HY-155507 c-Myc inhibitor 11 Inhibitor / Unkown
HY-155508 c-Myc inhibitor 12 Inhibitor / Unkown
HY-156673 m-Se3 Inhibitor / Unkown
HY-158062 LC-1-40 / Unkown
HY-160409 TopBP1-IN-1 / Unkown
HY-160549 c-Myc inhibitor 14 Inhibitor / Unkown
HY-160689 GW694590A Inhibitor / Unkown
HY-161127 NT-B2R Inhibitor / Unkown
HY-162294 c-Myc inhibitor 13 Inhibitor / Unkown
HY-162460 ERK1/2 inhibitor 10 Inhibitor / Unkown
HY-162469 6K465 Inhibitor / Unkown
HY-163108 ATAD2-IN-1 / Unkown
HY-N11576 Secalonic acid D / Unkown
HY-RS08877 MYC Human Pre-designed siRNA Set A / Unkown
HY-RS08878 Myc Mouse Pre-designed siRNA Set A / Unkown
HY-RS08879 Myc Rat Pre-designed siRNA Set A / Unkown
HY-W011616 Cardionogen 1 Inhibitor ≥99.0% Unkown
HY-130369 NSC10010 hydrochloride / Unkown
HY-156084 LL-K9-3 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myc NCBI NCBI:4609
Macaca fascicularis Myc NCBI NCBI:102127966
Susscrofa domestica Myc NCBI
Leporidae Myc NCBI
Rattus norvegicus Myc NCBI NCBI:24577