2. Gene
  3. Nras - neuroblastoma ras oncogene Gene

Nras - neuroblastoma ras oncogene Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as N-ras

Gene ID: 18176 | Gene type: protein coding

About Nras

Chromosome 3: 102,965,601-102,975,230 forward strand.GRCm39:CM000996.3

This gene has 9 transcripts (splice variants), 152 orthologues, 35 paralogues and is associated with 18 phenotypes.

Summary

Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in positive regulation of angiogenesis. Acts upstream of or within several processes, including T cell receptor signaling pathway; defense response to protozoan; and positive regulation of interferon-gamma production. Located in membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland Cancer (multiple); hematologic Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Nras Products(7)

mRNA Protein Name
NM_001410509.1 NP_001397438.1 GTPase NRas
NM_001368638.2 NP_001355567.1 GTPase NRas
NM_001410512.1 NP_001397441.1 GTPase NRas
NM_001410511.1 NP_001397440.1 GTPase NRas
NM_010937.3 NP_035067.2 GTPase NRas
NM_001410510.1 NP_001397439.1 GTPase NRas
NM_001410513.1 NP_001397442.1 GTPase NRas

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15136 Lonafarnib 99.87% Yes
Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156498 RMC-7977 Inhibitor 99.12% Unkown
HY-15217 CHR-6494 Inhibitor 98.07% Unkown
HY-122862 RAS inhibitor Abd-7 Inhibitor 99.16% Unkown
HY-142161 ABD957 Inhibitor 99.46% Unkown
HY-158115 NST-628 Inhibitor / Unkown
HY-122866 ZT-12-037-01 Inhibitor 98.67% Unkown
HY-156228 RGB-1 98.07% Unkown
HY-107415 PLX7922 Inhibitor 98.00% Unkown
HY-15879 LB42708 ≥99.0% Unkown
HY-108887 Anticancer agent 124 Inhibitor / Unkown
HY-110350 CHR-6494 TFA Inhibitor / Unkown
HY-120911 Palmostatin B Inhibitor / Unkown
HY-12847 CCT241161 / Unkown
HY-149705 ICMT-IN-7 Inhibitor / Unkown
HY-15136B (Rac)-Lonafarnib / Unkown
HY-156500 ICMT-IN-1 Inhibitor / Unkown
HY-163515 Anticancer agent 207 Inhibitor / Unkown
HY-RS09558 NRAS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09559 Nras Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09560 Nras Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-101641 NRA-0160 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nras NCBI NCBI:4893