Prkci - protein kinase C, iota Gene

Mus musculus

Also known as Pkci; Pkcl; Prkcl; PKClambda; mKIAA4165; aPKClambda; 2310021H13Rik

Gene ID: 18759 | Gene type: protein coding

About Prkci

Chromosome 3: 31,049,896-31,107,108 forward strand.GRCm39:CM000996.3

This gene has 5 transcripts (splice variants), 228 orthologues, 9 paralogues and is associated with 18 phenotypes. Ubiquitous expression in bladder adult (RPKM 26.7), placenta adult (RPKM 19.4) and 28 other tissues.

Summary

Enables protein kinase C activity. Involved in several processes, including cellular response to Insulin stimulus; positive regulation of glucose import; and positive regulation of protein localization to plasma membrane. Acts upstream of or within actin filament organization; establishment of apical/basal cell polarity; and eye photoreceptor cell development. Located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Used to study abdominal obesity-metabolic syndrome; obesity; and type 2 diabetes mellitus. Orthologous to human PRKCI (protein kinase C iota). [provided by Alliance of Genome Resources, Apr 2022]

Prkci Products(1)

mRNA	Protein	Name
NM_008857.3	NP_032883.2	protein kinase C iota type

Prkci Protein Structure

PB1_aPKC

C1_aPKC

STKc_aPKC_iota

0
100
200
300
400
500
595 a.a.

Protein Preferred Names

Protein Names

protein kinase C iota type

aPKC-lambda/iota	atypical protein kinase C-lambda/iota
nPKC-iota	protein kinase C, lambda

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS11134	PRKCI Human Pre-designed siRNA Set A	/	Unkown
HY-RS11135	Prkci Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11136	Prkci Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkci	NCBI	NCBI:5584

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