2. Gene
  3. Pten - phosphatase and tensin homolog Gene

Pten - phosphatase and tensin homolog Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TEP1; MMAC1; PTENbeta; 2310035O07Rik; A130070J02Rik; B430203M17Rik

Gene ID: 19211 | Gene type: protein coding

About Pten

Chromosome 19: 32,734,897-32,803,560 forward strand.GRCm39:CM001012.3

This gene has 3 transcripts (splice variants), 139 orthologues, 5 paralogues and is associated with 117 phenotypes. Ubiquitous expression in frontal lobe adult (RPKM 14.6), cortex adult (RPKM 12.9) and 28 other tissues.

Summary

This gene encodes a Phosphatase with dual activity against Phospholipids and proteins, and acts as a tumor-suppressor. The protein contains four structural domains, a PIP2-binding domain, a catalytic tensin-type Phosphatase domain, a C2 tensin-type domain and a PDZ-binding domain. The protein belongs to the protein tyrosine Phosphatase family. Deletion of this gene in mice contribute to tumorigenesis in multiple tissues. [provided by RefSeq, Sep 2015]

Pten Products(1)

mRNA Protein Name
NM_008960.2 NP_032986.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Pten Protein Structure

PTP_PTEN

PTP_PTEN: cd14509 (23 - 180)

PTEN_C2

PTEN_C2: pfam10409 (187 - 348)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

PTENepsilon

mitochondrial PTENalpha

mutated in multiple advanced cancers 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13074 VO-Ohpic trihydrate Inhibitor ≥98.0% Unkown
HY-15842 SF1670 Inhibitor ≥98.0% Unkown
HY-128693 BpV(HOpic) Inhibitor ≥98.0% Unkown
HY-N1435 Oroxin B Activator 99.71% Unkown
HY-N1441 Afzelin 99.62% Unkown
HY-122818 bpV(phen) trihydrate Inhibitor ≥98.0% Unkown
HY-N2116 Ginkgolic acid C17:1 Inhibitor 99.90% Unkown
HY-160093 SQLE-IN-1 Inducer 98.82% Unkown
HY-136065 bpV(phen) Inhibitor / Unkown
HY-110067 VO-OHPic Inhibitor / Unkown
HY-N8884 Coelonin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pten NCBI NCBI:5728