2. Gene
  3. NLRC3 - NLR family CARD domain containing 3 Gene

NLRC3 - NLR family CARD domain containing 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NOD3; CLR16.2

Gene ID: 197358 | Gene type: protein coding

About NLRC3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,539,033-3,577,403 (from NCBI)

This gene has 5 transcripts (splice variants), 194 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 6.9), spleen (RPKM 4.9) and 23 other tissues.

Summary

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

NLRC3 Products(1)

mRNA Protein Name
NM_178844.4 NP_849172.2 NLR family CARD domain-containing protein 3

NLRC3 Protein Structure

NACHT

NACHT: NACHT domain (139 - 304)

LRR_6

LRR_6: Leucine Rich repeat (667 - 687)

LRR_6

LRR_6: Leucine Rich repeat (693 - 715)

LRR_6

LRR_6: Leucine Rich repeat (721 - 743)

LRR_6

LRR_6: Leucine Rich repeat (776 - 799)

LRR_6

LRR_6: Leucine Rich repeat (805 - 825)

LRR_6

LRR_6: Leucine Rich repeat (832 - 854)

LRR_6

LRR_6: Leucine Rich repeat (888 - 910)

LRR_6

LRR_6: Leucine Rich repeat (944 - 967)

LRR_6

LRR_6: Leucine Rich repeat (1001 - 1022)

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  • 1036 a.a.
Protein Preferred Names Protein Names

NLR family CARD domain-containing protein 3

CARD15-like protein

Related Diseases

Diseases Alias
Cicatricial Entropion
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09346 NLRC3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NLRC3 VGNC VGNC:43843
Macaca mulatta NLRC3 VGNC VGNC:75282
Felis catus NLRC3 VGNC VGNC:63826
Rattus norvegicus NLRC3 RGD RGD:1304902
Mus musculus NLRC3 MGD MGI:2444070
Bos taurus NLRC3 VGNC VGNC:32112