2. Gene
  3. CRTC2 - CREB regulated transcription coactivator 2 Gene

CRTC2 - CREB regulated transcription coactivator 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TORC2; TORC-2

Gene ID: 200186 | Gene type: protein coding

About CRTC2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,947,675-153,958,612 (from NCBI)

This gene has 10 transcripts (splice variants), 237 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 17.9), bone marrow (RPKM 17.3) and 25 other tissues.

Summary

This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]

CRTC2 Products(1)

mRNA Protein Name
NM_181715.3 NP_859066.1 CREB-regulated transcription coactivator 2

CRTC2 Protein Structure

TORC_N

TORC_N: Transducer of regulated CREB activity, N terminus (18 - 71)

TORC_M

TORC_M: Transducer of regulated CREB activity middle domain (168 - 320)

TORC_C

TORC_C: Transducer of regulated CREB activity, C terminus (615 - 692)

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  • 693 a.a.
Protein Preferred Names Protein Names

CREB-regulated transcription coactivator 2

transducer of regulated cAMP response element-binding protein (CREB) 2

Related Diseases

Diseases Alias
Human T-Cell Leukemia Virus Type 1

Htlv-1

Human T Lymphotropic Virus Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03201 CRTC2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CRTC2 RGD RGD:1308903
Macaca mulatta CRTC2 VGNC VGNC:71597
Bos taurus CRTC2 VGNC VGNC:97256
Mus musculus CRTC2 MGD MGI:1921593
Canis familiaris CRTC2 VGNC VGNC:53339
Felis catus CRTC2 VGNC VGNC:61193