2. Gene
  3. Tnfrsf11a - tumor necrosis factor receptor superfamily, member 11a, NFKB activator Gene

Tnfrsf11a - tumor necrosis factor receptor superfamily, member 11a, NFKB activator Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R

Gene ID: 21934 | Gene type: protein coding

About Tnfrsf11a

Chromosome 1: 105,708,443-105,775,709 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 493 orthologues, 21 paralogues and is associated with 51 phenotypes. Biased expression in colon adult (RPKM 2.9), duodenum adult (RPKM 8.1) and 1 other tissues.

Summary

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including circadian temperature homeostasis; positive regulation of fever generation by positive regulation of prostaglandin secretion; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; mammary gland alveolus development; and positive regulation of bone resorption. Located in cell surface. Is expressed in bladder and lymphatic system. Human ortholog(s) of this gene implicated in Paget's disease of bone; autosomal recessive osteopetrosis 7; bone development disease; familial expansile osteolysis; and osteoporosis. Orthologous to human TNFRSF11A (TNF Receptor Superfamily member 11a). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf11a Products(1)

mRNA Protein Name
NM_009399.5 NP_033425.3 tumor necrosis factor receptor superfamily member 11A precursor

Tnfrsf11a Protein Structure

TNFRSF11A

TNFRSF11A: cd13411 (33 - 195)

TNFRSF11A

TNFRSF11A: cd13411 (34 - 68)

TNFRSF11A

TNFRSF11A: cd13411 (71 - 112)

TNFRSF11A

TNFRSF11A: cd13411 (114 - 151)

TNFRSF11A

TNFRSF11A: cd13411 (154 - 194)

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  • 625 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 11A

osteoclast differentiation factor receptor

receptor activator of NF-KB

receptor activator of NF-kappaB

Recombinant Tnfrsf11a Proteins

Cat. No. Product Name Accession Purity
HY-P72483 RANK/TNFRSF11A Protein, Mouse (HEK293, His) O35305 (V31-S214) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14799 TNFRSF11A Human Pre-designed siRNA Set A / Unkown
HY-RS14800 Tnfrsf11a Mouse Pre-designed siRNA Set A / Unkown
HY-RS14801 Tnfrsf11a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnfrsf11a NCBI NCBI:8792
Rattus norvegicus Tnfrsf11a NCBI NCBI:498206