RTKN2 - rhotekin 2 Gene

Homo sapiens

Also known as PLEKHK1; bA531F24.1

Gene ID: 219790 | Gene type: protein coding

About RTKN2

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:62,183,900-62,268,844 (from NCBI)

This gene has 3 transcripts (splice variants), 199 orthologues and 2 paralogues. Biased expression in lung (RPKM 32.1) and testis (RPKM 2.2).

Summary

Involved in negative regulation of intrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of NIK/NF-kappaB signaling. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RTKN2 Products(2)

mRNA	Protein	Name
NM_001282941.2	NP_001269870.1	rhotekin-2 isoform 2
NM_145307.4	NP_660350.2	rhotekin-2 isoform 1

RTKN2 Protein Structure

Anillin

0
100
200
300
400
500
609 a.a.

Protein Preferred Names

Protein Names

rhotekin-2

PH domain-containing family K member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12321	RTKN2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RTKN2	VGNC	VGNC:64808
Canis familiaris	RTKN2	VGNC	VGNC:45790
Bos taurus	RTKN2	VGNC	VGNC:34198
Macaca mulatta	RTKN2	VGNC	VGNC:77055
Mus musculus	RTKN2	MGD	MGI:2158417
Rattus norvegicus	RTKN2	RGD	RGD:1304834

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