DOK6 - docking protein 6 Gene

Homo sapiens

Also known as DOK5L; HsT3226

Gene ID: 220164 | Gene type: protein coding

About DOK6

Cytogenetic location: 18q22.2 Genomic coordinates (GRCh38): 18:69,400,888-69,849,087 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 7 paralogues. Biased expression in brain (RPKM 6.3), kidney (RPKM 1.5) and 10 other tissues.

Summary

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]

DOK6 Products(1)

mRNA	Protein	Name
NM_152721.6	NP_689934.2	docking protein 6

DOK6 Protein Structure

IRS

0
100
200
300
331 a.a.

Protein Preferred Names

Protein Names

docking protein 6

downstream of tyrosine kinase 6

Related Diseases

Diseases

Alias

Malignant Iris Melanoma

Malignant Melanoma Of Iris

Melanoma Of The Iris

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03938	DOK6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DOK6	VGNC	VGNC:61585
Mus musculus	DOK6	MGD	MGI:3639495
Bos taurus	DOK6	VGNC	VGNC:28169
Macaca mulatta	DOK6	VGNC	VGNC:71915
Rattus norvegicus	DOK6	RGD	RGD:1564376
Canis familiaris	DOK6	VGNC	VGNC:40060