2. Gene
  3. Tshr - thyroid stimulating hormone receptor Gene

Tshr - thyroid stimulating hormone receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as hyt; pet; hypothroid

Gene ID: 22095 | Gene type: protein coding

About Tshr

Chromosome 12: 91,351,337-91,516,582 forward strand.GRCm39:CM001005.3

This gene has 5 transcripts (splice variants), 260 orthologues, 2 paralogues and is associated with 66 phenotypes. Biased expression in subcutaneous fat pad adult (RPKM 19.7), genital fat pad adult (RPKM 11.8) and 3 other tissues.

Summary

Enables thyroid-stimulating hormone receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including adult locomotory behavior; dopaminergic neuron differentiation; and inner ear development. Located in plasma membrane. Is expressed in bladder; renal vasculature; thyroid gland; and thyroid gland lobe. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves' disease; cardiomyopathy; congenital nongoitrous hypothyroidism 1; and mitral valve prolapse. Orthologous to human TSHR (thyroid stimulating hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]

Tshr Products(2)

mRNA Protein Name
NM_011648.5 NP_035778.3 thyrotropin receptor isoform 1 precursor
NM_001113404.1 NP_001106875.1 thyrotropin receptor isoform 2 precursor

Tshr Protein Structure

LRR_RI

LRR_RI: sd00033 (53 - 76)

LRR_5

LRR_5: cl37855 (64 - 220)

LRR_RI

LRR_RI: sd00033 (77 - 101)

LRR_RI

LRR_RI: sd00033 (102 - 126)

LRR_RI

LRR_RI: sd00033 (127 - 151)

LRR_RI

LRR_RI: sd00033 (152 - 176)

LRR_RI

LRR_RI: sd00033 (180 - 200)

LRR_RI

LRR_RI: sd00033 (201 - 225)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (414 - 688)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (415 - 441)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (448 - 473)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (493 - 523)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (535 - 557)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (577 - 606)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (616 - 646)

7tmA_TSH-R

7tmA_TSH-R: cd15964 (656 - 681)

  • 0
  • 200
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  • 600
  • 764 a.a.
Protein Preferred Names Protein Names

thyrotropin receptor

TSH-R

Related Agents

Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12381 ML224 Antagonist 99.71% Unkown
HY-114116 ML-109 Agonist 99.12% Unkown
HY-129995A TSHR antagonist S37a Antagonist 98.00% Unkown
HY-150210 FSHR agonist 1 Agonist 98.48% Unkown
HY-122974 VA-K-14 hydrochloride Antagonist 98.20% Unkown
HY-100271 Org41841 Agonist 99.46% Unkown
HY-124867 D3-βArr Modulator 99.83% Unkown
HY-18286 NCGC00229600 Antagonist 99.86% Unkown
HY-158100 SYD5115 Antagonist / Unkown
HY-129995 TSHR antagonist S37b Inhibitor 99.06% Unkown
HY-RS15145 TSHR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS15146 Tshr Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS15147 Tshr Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-114918 MS438 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tshr NCBI NCBI:7253