OARD1 - O-acyl-ADP-ribose deacylase 1 Gene

Homo sapiens

Also known as TARG1; C6orf130; dJ34B21.3

Gene ID: 221443 | Gene type: protein coding

About OARD1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,064,772-41,097,787 (from NCBI)

This gene has 16 transcripts (splice variants) and 240 orthologues. Ubiquitous expression in testis (RPKM 36.5), thyroid (RPKM 20.0) and 25 other tissues.

Summary

The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inhibit these reactions through a competitive feedback loop. [provided by RefSeq, Jul 2016]

OARD1 Products(13)

mRNA	Protein	Name
NM_001329684.2	NP_001316613.1	ADP-ribose glycohydrolase OARD1 isoform a
NM_001329685.1	NP_001316614.1	ADP-ribose glycohydrolase OARD1 isoform a
NM_001329686.2	NP_001316615.1	ADP-ribose glycohydrolase OARD1 isoform a
NM_001329688.2	NP_001316617.1	ADP-ribose glycohydrolase OARD1 isoform a
NM_001329689.2	NP_001316618.1	ADP-ribose glycohydrolase OARD1 isoform b
NM_001329690.2	NP_001316619.1	ADP-ribose glycohydrolase OARD1 isoform c
NM_001329691.2	NP_001316620.1	ADP-ribose glycohydrolase OARD1 isoform c
NM_001329692.1	NP_001316621.1	ADP-ribose glycohydrolase OARD1 isoform c
NM_001329693.2	NP_001316622.1	ADP-ribose glycohydrolase OARD1 isoform c
NM_001329694.2	NP_001316623.1	ADP-ribose glycohydrolase OARD1 isoform d
NM_001329695.1	NP_001316624.1	ADP-ribose glycohydrolase OARD1 isoform d
NM_001329696.2	NP_001316625.1	ADP-ribose glycohydrolase OARD1 isoform d
NM_145063.4	NP_659500.1	ADP-ribose glycohydrolase OARD1 isoform a

OARD1 Protein Structure

Macro

0
100
152 a.a.

Protein Preferred Names

Protein Names

ADP-ribose glycohydrolase OARD1

O-acetyl-ADP-ribose deacetylase 1

Recombinant OARD1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71658	OARD1 Protein, Human (Myc, His)	Q9Y530 (2A-152L)	≥95%

Related Diseases

Diseases

Alias

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

Brachydactyly, Type A4

Brachymesophalangy Ii And V	Temtamy Type Brachydactyly
Brachydactyly Type A4	BDA4
Brachymesophalangy 2 And 5	Brachydactyly Temtamy Type
Brachydactyly, Temtamy Type

Eastern Equine Encephalitis

Eee	Neuroinvasive Eastern Equine Encephalitis Virus Infection
Eastern Equine Encephalomyelitis	Encephalomyelitis, Eastern Equine
Triple E	Eastern Equine Encephalitis Virus Infection
Neuroinvasive Eastern Equine Encephalitis Virus Disease	Eee - [Eastern Equine Encephalitis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09726	OARD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	OARD1	VGNC	VGNC:32390
Felis catus	OARD1	VGNC	VGNC:102477
Canis familiaris	OARD1	VGNC	VGNC:44085
Mus musculus	OARD1	MGD	MGI:2146818
Rattus norvegicus	OARD1	RGD	RGD:1308299
Macaca mulatta	OARD1	VGNC	VGNC:75444
Others	OARD1	NCBI

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