2. Gene
  3. GPRC6A - G protein-coupled receptor class C group 6 member A Gene

GPRC6A - G protein-coupled receptor class C group 6 member A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GPCR; bA86F4.3

Gene ID: 222545 | Gene type: protein coding

About GPRC6A

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:116,792,085-116,829,240 (from NCBI)

This gene has 3 transcripts (splice variants), 218 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

Members of family C of the G protein-coupled receptor (GPCR) superfamily, such as GPRC6A, are characterized by an evolutionarily conserved amino acid-sensing motif linked to an intramembranous 7-transmembrane loop region. Several members of GPCR family C, including GPRC6A, also have a long N-terminal domain (summary by Pi et al., 2005 [PubMed 16199532]).[supplied by OMIM, Nov 2010]

GPRC6A Products(3)

mRNA Protein Name
NM_001286354.1 NP_001273283.1 G-protein coupled receptor family C group 6 member A isoform 2 precursor
NM_001286355.1 NP_001273284.1 G-protein coupled receptor family C group 6 member A isoform 3 precursor
NM_148963.4 NP_683766.2 G-protein coupled receptor family C group 6 member A isoform 1 precursor

GPRC6A Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (75 - 479)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (519 - 571)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (603 - 837)

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  • 926 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor family C group 6 member A

G protein-coupled receptor, family C, group 6, member A

Related Diseases

Diseases Alias
Hyperparathyroidism

Hyperparathyroidism And Other Disorders Of Parathyroid Gland

Parathyroid Hyperfunction

Hpth - [Hyperparathyroidism]

Parathyroid Gland Hyperfunction

Parathyroid Glandular Hyperfunction
Ocular Albinism

Albinism, Ocular

Oa

Xloa

Albinism Ocular
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114165 DJ-V-159 Agonist 99.62% Unkown
HY-RS05753 GPRC6A Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GPRC6A VGNC VGNC:41452
Macaca mulatta GPRC6A VGNC VGNC:72965
Felis catus GPRC6A VGNC VGNC:102433
Rattus norvegicus GPRC6A RGD RGD:735077
Mus musculus GPRC6A MGD MGI:2429498