Rorb - RAR-related orphan receptor beta Gene

Mus musculus

Also known as RZRB; hstp; Nr1f2; Rorbeta; RZR-beta

Gene ID: 225998 | Gene type: protein coding

About Rorb

Chromosome 19: 18,907,969-19,088,560 reverse strand.GRCm39:CM001012.3

This gene has 5 transcripts (splice variants), 398 orthologues, 19 paralogues and is associated with 36 phenotypes. Biased expression in cortex adult (RPKM 5.3), frontal lobe adult (RPKM 2.8) and 5 other tissues.

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Rorb Products(3)

mRNA	Protein	Name
NM_001043354.2	NP_001036819.1	nuclear receptor ROR-beta isoform 1
NM_001289921.1	NP_001276850.1	nuclear receptor ROR-beta isoform 3
NM_146095.4	NP_666207.3	nuclear receptor ROR-beta isoform 2

Rorb Protein Structure

NR_DBD_ROR

NR_LBD_ROR_like

0
100
200
300
400
459 a.a.

Protein Preferred Names

Protein Names

nuclear receptor ROR-beta

nuclear receptor RZR-beta	nuclear receptor subfamily 1 group F member 2
retinoid-related orphan receptor-beta

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS12129	RORB Human Pre-designed siRNA Set A	/	Unkown
HY-RS12130	Rorb Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS12131	Rorb Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rorb	NCBI	NCBI:6096

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