2. Gene
  3. Dyrk3 - dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 Gene

Dyrk3 - dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 226419 | Gene type: protein coding

About Dyrk3

Chromosome 1: 131,055,192-131,066,077 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 201 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in testis adult (RPKM 67.2), liver E14.5 (RPKM 1.2) and 7 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including erythrocyte differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; and protein phosphorylation. Predicted to be located in several cellular components, including cytoplasmic stress granule; nuclear speck; and pericentriolar material. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; musculature; nasal cavity epithelium; and reproductive system. Orthologous to human DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk3 Products(1)

mRNA Protein Name
NM_145508.2 NP_663483.1 dual specificity tyrosine-phosphorylation-regulated kinase 3

Dyrk3 Protein Structure

PKc_DYRK2_3

PKc_DYRK2_3: cd14224 (141 - 520)

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  • 586 a.a.
Protein Preferred Names Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 3

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-105309 GSK-626616 Inhibitor 99.68% Phase 1
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-155723 Leucettinib-92 Inhibitor / Unkown
HY-RS04102 Dyrk3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04103 Dyrk3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dyrk3 NCBI NCBI:8444