2. Gene
  3. SLC9A8 - solute carrier family 9 member A8 Gene

SLC9A8 - solute carrier family 9 member A8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NHE8; NHE-8

Gene ID: 23315 | Gene type: protein coding

About SLC9A8

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,812,828-49,892,242 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues and 10 paralogues. Ubiquitous expression in bone marrow (RPKM 8.0), testis (RPKM 5.3) and 25 other tissues.

Summary

Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]

SLC9A8 Products(2)

mRNA Protein Name
NM_001260491.2 NP_001247420.1 sodium/hydrogen exchanger 8 isoform 1
NM_015266.3 NP_056081.1 sodium/hydrogen exchanger 8 isoform 2

SLC9A8 Protein Structure

Na_H_Exchanger

Na_H_Exchanger: Sodium/hydrogen exchanger family (69 - 472)

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  • 581 a.a.
Protein Preferred Names Protein Names

sodium/hydrogen exchanger 8

Na(+)/H(+) exchanger 8

Related Diseases

Diseases Alias
Christianson Syndrome

X-Linked Angelman-Like Syndrome

X-Linked Intellectual Disability, South African Type

X-Linked Intellectual Disability-Craniofacial Dysmorphism-Epilepsy-Ophthalmoplegia-Cerebellar Atrophy Syndrome

Mental Retardation, Microcephaly, Epilepsy, And Ataxia Syndrome

Mental Retardation, X-Linked Syndromic, Christianson Type

Mrxsch

Angelman-Like Syndrome X-Linked

Intellectual Disability Microcephaly Epilepsy And Ataxia Syndrome

Intellectual Disability X-Linked Syndromic Christianson Type

Mrxs Christianson

X-Linked Intellectual Disability - Craniofacial Dysmorphism - Epilepsy - Ophthalmoplegia - Cerebellar Atrophy

Angelman-Like Syndrome, X-Linked

Intellectual Deficit, X-Linked, South African Type

Mental Retardation X-Linked, South African Type

Mental Retardation, X-Linked, Syndromic, Christianson Type
Corneal Dystrophy, Band-Shaped

Band Keratopathy

Band-Shaped Keratopathy
Inflammatory Diarrhea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13347 SLC9A8 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC9A8 VGNC VGNC:77749
Rattus norvegicus SLC9A8 RGD RGD:1308193
Bos taurus SLC9A8 VGNC VGNC:34946
Canis familiaris SLC9A8 VGNC VGNC:46490
Mus musculus SLC9A8 MGD MGI:1924281
Felis catus SLC9A8 VGNC VGNC:65439