CUX2 - cut like homeobox 2 Gene

Homo sapiens

Also known as CDP2; CUTL2; DEE67; EIEE67

Gene ID: 23316 | Gene type: protein coding

About CUX2

Cytogenetic location: 12q24.11-q24.12 Genomic coordinates (GRCh38): 12:111,034,165-111,350,554 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in prostate (RPKM 4.9), liver (RPKM 4.6) and 3 other tissues.

Summary

This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]

CUX2 Products(2)

mRNA	Protein	Name
NM_001370598.1	NP_001357527.1	homeobox protein cut-like 2 isoform 2
NM_015267.4	NP_056082.2	homeobox protein cut-like 2 isoform 1

CUX2 Protein Structure

CUT

Homeobox

0
300
600
900
1200
1486 a.a.

Protein Preferred Names

Protein Names

homeobox protein cut-like 2

homeobox protein cux-2

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 67

DEE67	Epileptic Encephalopathy, Early Infantile, 67
Eiee67	Developmental And Epileptic Encephalopathy, 67
Early Infantile Epileptic Encephalopathy 67

Thrombocythemia 1

THCYT1	Thrombocytosis 1
Thrombocythemia, Somatic	Essential Thrombocythemia
Thrombocythemia, Essential

Essential Thrombocythemia

Essential Thrombocytosis	Familial Thrombocytosis
Hemorrhagic Thrombocythemia	Hereditary Thrombocythemia
Primary Thrombocytosis	Idiopathic Thrombocythemia
Primary Thrombocythemia	Thrombocythemia, Essential
Essential Thrombocythaemia	Et
Familial Thrombocythemia	Thrombocythemia Essential

Lennox-Gastaut Syndrome

Lennox Syndrome	Encephalopathy Of Childhood
Epileptic Encephalopathy Lennox-Gastaut Type	Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves
Lgs

Fiedler'S Myocarditis

Isolated Myocarditis	Fiedler Myocarditis
Idiopathic Myocarditis

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03370	CUX2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CUX2	VGNC	VGNC:82348
Canis familiaris	CUX2	VGNC	VGNC:39739
Rattus norvegicus	CUX2	RGD	RGD:1305967
Bos taurus	CUX2	VGNC	VGNC:27840
Mus musculus	CUX2	MGD	MGI:107321
Macaca mulatta	CUX2	VGNC	VGNC:71443