NCS1 - neuronal calcium sensor 1 Gene

Homo sapiens

Also known as FLUP; FREQ

Gene ID: 23413 | Gene type: protein coding

About NCS1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:130,172,404-130,237,303 (from NCBI)

This gene has 3 transcripts (splice variants), 120 orthologues and 14 paralogues. Biased expression in brain (RPKM 60.4), esophagus (RPKM 14.4) and 11 other tissues.

Summary

This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for Calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NCS1 Products(2)

mRNA	Protein	Name
NM_001128826.2	NP_001122298.1	neuronal calcium sensor 1 isoform 2
NM_014286.4	NP_055101.2	neuronal calcium sensor 1 isoform 1

NCS1 Protein Structure

EF-hand_1

EF-hand_7

0
100
190 a.a.

Protein Preferred Names

Protein Names

neuronal calcium sensor 1

frequenin homolog

Related Diseases

Diseases

Alias

Wolfram Syndrome

Didmoad Syndrome	Didmoad
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Wfs
Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness	Didmoadud
Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome	Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Wolfram Syndrome 2

WFS2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122579	IGS-1.76	Inhibitor	98.56%	Unkown
HY-N2037C	(S)-Higenamine hydrobromide		≥97.0%	Unkown
HY-W012653	4'-Methylacetophenone		98.71%	Unkown
HY-N2037B	(S)-Higenamine		/	Unkown
HY-RS09102	NCS1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NCS1	RGD	RGD:68417
Canis familiaris	NCS1	VGNC	VGNC:43667
Bos taurus	NCS1	VGNC	VGNC:31928
Felis catus	NCS1	VGNC	VGNC:63744
Mus musculus	NCS1	MGD	MGI:109166

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