2. Gene
  3. Parp3 - poly (ADP-ribose) polymerase family, member 3 Gene

Parp3 - poly (ADP-ribose) polymerase family, member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ARTD3; Adprt3; PARP-3; ADPRT-3; Adprtl3; pADPRT-3; A930002C11Rik

Gene ID: 235587 | Gene type: protein coding

About Parp3

Chromosome 9: 106,347,521-106,354,148 reverse strand.GRCm39:CM001002.3

This gene has 9 transcripts (splice variants), 198 orthologues and 2 paralogues. Broad expression in subcutaneous fat pad adult (RPKM 25.), bladder adult (RPKM 19.6) and 18 other tissues.

Summary

Predicted to enable NAD DNA ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; and protein ADP-ribosylase activity. Involved in negative regulation of isotype switching. Acts upstream of or within double-strand break repair. Located in site of double-strand break. Orthologous to human PARP3 (poly(ADP-ribose) polymerase family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Parp3 Products(2)

mRNA Protein Name
NM_001311150.1 NP_001298079.1 protein mono-ADP-ribosyltransferase PARP3 isoform 1
NM_145619.3 NP_663594.2 protein mono-ADP-ribosyltransferase PARP3 isoform 2

Parp3 Protein Structure

WGR

WGR: cl01581 (55 - 153)

parp_like

parp_like: cd01437 (175 - 526)

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  • 528 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP3

A DP-ribosyltransferase (NAD+

poly (ADP-ribose polymerase)-like 3

ADP-ribosyltransferase (NAD+, poly (ADP-ribose polymerase)-like 3

ADP-ribosyltransferase diphtheria toxin-like 3

DNA ADP-ribosyltransferase PARP3

NAD(+) ADP-ribosyltransferase 3

NAD+ ADP-ribosyltransferase 3

Poly[ADP-ribose] synthetase-3

poly [ADP-ribose] polymerase 3

poly[ADP-ribose] synthase 3

Related Agents

Approval
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10619 Niraparib Inhibitor 99.96% Yes
HY-10617A Rucaparib Inhibitor 99.80% Yes
HY-10619B Niraparib tosylate Inhibitor 99.99% Yes
HY-10619A Niraparib hydrochloride Inhibitor 99.76% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.82% Yes
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% Yes
HY-10617C Rucaparib tartrate Inhibitor / Unkown
HY-102003A Rucaparib camsylate Inhibitor / Unkown
HY-10617D Rucaparib acetate Inhibitor / Unkown
HY-10617B Rucaparib hydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13536 AZD-2461 Inhibitor 99.88% Phase 1
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150207 RBN-3143 Inhibitor 99.24% Unkown
HY-100225 ME0328 Inhibitor 99.59% Unkown
HY-148566 OUL232 Inhibitor 99.82% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.89% Unkown
HY-155993 YCH1899 Inhibitor / Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.02% Unkown
HY-W294889 OUL245 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parp3 NCBI NCBI:10039