MAFF - MAF bZIP transcription factor F Gene

Homo sapiens

Also known as U-MAF; hMafF

Gene ID: 23764 | Gene type: protein coding

About MAFF

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,201,994-38,216,511 (from NCBI)

This gene has 8 transcripts (splice variants), 190 orthologues and 6 paralogues. Ubiquitous expression in gall bladder (RPKM 22.1), fat (RPKM 18.9) and 25 other tissues.

Summary

The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the Oxytocin Receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

MAFF Products(4)

mRNA	Protein	Name
NM_001161572.2	NP_001155044.1	transcription factor MafF isoform a
NM_001161573.1	NP_001155045.1	transcription factor MafF isoform a
NM_001161574.2	NP_001155046.1	transcription factor MafF isoform b
NM_012323.4	NP_036455.1	transcription factor MafF isoform a

MAFF Protein Structure

bZIP_Maf

0
100
164 a.a.

Protein Preferred Names

Protein Names

transcription factor MafF

v-maf avian musculoaponeurotic fibrosarcoma oncogene family protein F

Related Diseases

Diseases

Alias

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy

Autosomal Dominant Adult-Onset Proximal Sma	Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type
Finkel Disease	Smafk
Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant	Autosomal Dominant Adult Proximal Spinal Muscular Atrophy
Finkel Late-Adult Type Sma

Multicentric Carpotarsal Osteolysis Syndrome

Multicentric Carpo-Tarsal Osteolysis With Or Without Nephropathy	MCTO
Osteolysis, Hereditary, Of Carpal Bones With Or Without Nephropathy	Idiopathic Multicentric Osteolysis With Or Without Nephropathy
Autosomal Dominant Multicentric Osteolysis	Hereditary Osteolysis Of Carpal Bones With Or Without Nephropathy
Multicentric Osteolysis, Autosomal Dominant	Multicentric Osteolysis Nephropathy
Osteolysis, Carpotarsal, Multicentric Syndrome	Lytic Lesion

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07960	MAFF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAFF	VGNC	VGNC:31140
Macaca mulatta	MAFF	VGNC	VGNC:95357
Mus musculus	MAFF	MGD	MGI:96910
Rattus norvegicus	MAFF	RGD	RGD:1309531
Canis familiaris	MAFF	VGNC	VGNC:49919