2. Gene
  3. Mmp17 - matrix metallopeptidase 17 Gene

Mmp17 - matrix metallopeptidase 17 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MT4MMP; MTMMP4; MT4-MMP

Gene ID: 23948 | Gene type: protein coding

About Mmp17

Chromosome 5: 129,661,233-129,688,163 forward strand.GRCm39:CM000998.3

This gene has 2 transcripts (splice variants), 257 orthologues, 23 paralogues and is associated with 8 phenotypes. Broad expression in cortex adult (RPKM 21.7), frontal lobe adult (RPKM 16.4) and 17 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme. Mice lacking the encoded protein exhibit dysfunctional vascular smooth muscle cells and altered extracellular matrix in the vessel wall leading to an increased susceptibility to angiotensin-II-induced thoracic aortic aneurysm. [provided by RefSeq, Feb 2016]

Mmp17 Products(1)

mRNA Protein Name
NM_011846.5 NP_035976.3 matrix metalloproteinase-17 preproprotein

Mmp17 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (43 - 103)

ZnMc_MMP

ZnMc_MMP: cd04278 (130 - 293)

HX

HX: cd00094 (332 - 526)

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  • 578 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-17

membrane-type matrix metalloproteinase 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-RS08533 MMP17 Human Pre-designed siRNA Set A / Unkown
HY-RS08534 Mmp17 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08535 Mmp17 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp17 NCBI NCBI:4326