Drd2 - dopamine receptor D2 Gene

Rattus norvegicus

Gene ID: 24318 | Gene type: protein coding

About Drd2

Primary_assembly 8: 49,708,927-49,772,875 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 207 orthologues, 23 paralogues and is associated with 63 phenotypes. Biased expression in Brain (RPKM 22.7) and Adrenal (RPKM 6.).

Summary

Enables several functions, including dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and ionotropic glutamate receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of protein modification process. Located in several cellular components, including cytoplasmic vesicle; lateral plasma membrane; and perikaryon. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study Parkinsonism; cocaine dependence; and ovarian hyperstimulation syndrome. Biomarker of several diseases, including Gilles de la Tourette syndrome; drug psychosis; hyperprolactinemia; opiate dependence (multiple); and toxic encephalopathy. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; mental depression; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (Dopamine Receptor D2). [provided by Alliance of Genome Resources, Apr 2022]

Drd2 Products(2)

mRNA	Protein	Name
NM_001409379.1	NP_001396308.1	D(2) dopamine receptor isoform 2
NM_012547.3	NP_036679.1	D(2) dopamine receptor isoform 1

Drd2 Protein Structure

7tmA_D2_dopamine_R

0
100
200
300
400
444 a.a.

Protein Preferred Names

Protein Names

D(2) dopamine receptor

dopamine receptor 2

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13736A	Quinagolide hydrochloride		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-135147	ONC206	Antagonist	99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120920	UNC9995	Agonist	99.38%	Unkown
HY-W040146	Propionylpromazine hydrochloride	Antagonist	95.01%	Unkown
HY-W040146S	Propionylpromazine-d6 hydrochloride	Antagonist	99.78%	Unkown
HY-125125	Danshenxinkun D		/	Unkown
HY-RS03997	DRD2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS03998	Drd2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS03999	Drd2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd2	NCBI	NCBI:1813

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