2. Gene
  3. Kras - KRAS proto-oncogene, GTPase Gene

Kras - KRAS proto-oncogene, GTPase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as p21; Kras2; c-Ki-ras

Gene ID: 24525 | Gene type: protein coding

About Kras

Biased expression in Lung (RPKM 85.5), Thymus (RPKM 74.) and 9 other tissues.

Summary

Enables GDP binding activity; GMP binding activity; and LRR domain binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cellular senescence; and response to corticosteroid. Located in membrane raft and mitochondrion. Used to study bronchiolo-alveolar adenocarcinoma; endometrial adenocarcinoma; hepatocellular adenoma; hepatocellular carcinoma; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system Cancer (multiple); and hematologic Cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Kras Products(1)

mRNA Protein Name
NM_031515.3 NP_113703.1 GTPase KRas

Kras Protein Structure

H_N_K_Ras_like

H_N_K_Ras_like: cd04138 (2 - 163)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

GTPase KRas

K-Ras 2

Kirsten rat sarcoma viral oncogene homolog

Kirsten rat sarcoma viral oncogene homologue 2 (active)

c-K-ras

c-K-ras2 protein

c-Kirsten-ras proto-oncogene

ki-Ras

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114277 Sotorasib Inhibitor 99.94% Yes
HY-15136 Lonafarnib 99.87% Yes
HY-114277A Sotorasib racemate 98.99% Unkown
Clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-130149 Adagrasib Inhibitor 99.93% Phase 3
HY-145928 Divarasib Inhibitor 99.46% Phase 3
HY-139612 Opnurasib Inhibitor 98.94% Phase 3
HY-134813 MRTX1133 Inhibitor 99.42% Phase 2
HY-114491 Rineterkib Inhibitor 99.83% Phase 2
HY-N6674 Diazepinomicin 98.04% Phase 2
HY-153346 RMC-6291 99.65% Phase 1
HY-15610 GDC-0623 99.15% Phase 1
HY-16373 CP-609754 Inhibitor 99.87% Phase 1
HY-156002 LUNA18 Inhibitor 99.26% Phase 1
Pre-clinical Phase
Bioactive Molecules (272)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153724 BI-2865 99.65% Unkown
HY-126247 BI-2852 Inhibitor 99.57% Unkown
HY-125817 BI-3406 Inhibitor 99.95% Unkown
HY-16909 Leptomycin B Inhibitor 99.54% Unkown
HY-112929 DT-061 Activator 99.95% Unkown
HY-114398 BAY-293 Inhibitor 95.77% Unkown
HY-147214 GNE-7883 Inhibitor 98.49% Unkown
HY-156498 RMC-7977 Inhibitor 99.12% Unkown
HY-137516 LC-2 Inhibitor ≥95.0% Unkown
HY-U00418 ARS-1620 Inhibitor 99.62% Unkown
HY-135985 DCLK1-IN-1 Inhibitor 99.62% Unkown
HY-15872A FTI-277 hydrochloride 98.00% Unkown
HY-114436 MRTX-1257 Inhibitor 99.14% Unkown
HY-148098 Pan KRas-IN-1 Inhibitor 98.47% Unkown
HY-156819 RMC-9805 Inhibitor 99.73% Unkown
HY-129523 PROTAC K-Ras Degrader-1 Inhibitor 98.05% Unkown
HY-W451275 HG106 Inhibitor 99.95% Unkown
HY-19713 LJI308 Inhibitor 99.07% Unkown
HY-128350 FGTI-2734 Inhibitor 99.64% Unkown
HY-148409 MMRi62 99.58% Unkown
HY-122862 RAS inhibitor Abd-7 Inhibitor 99.16% Unkown
HY-15747 Deltarasin Inhibitor 99.89% Unkown
HY-141477 RM-018 Inhibitor 98.03% Unkown
HY-153723 BI-2493 Inhibitor 99.70% Unkown
HY-19706 ARS-853 98.39% Unkown
HY-18674 K-Ras-IN-1 Inhibitor 98.05% Unkown
HY-138188 KRA-533 Agonist 98.94% Unkown
HY-158115 NST-628 Inhibitor / Unkown
HY-141807 MS21 99.88% Unkown
HY-132980 KRAS G12C inhibitor 19 Inhibitor 98.41% Unkown
HY-145571 Garsorasib Inhibitor 99.11% Unkown
HY-128350A FGTI-2734 mesylate Inhibitor 99.05% Unkown
HY-145962A MRTX-EX185 formic Inhibitor 97.32% Unkown
HY-151523 KRas G12R inhibitor 1 Inhibitor 98.19% Unkown
HY-122914 KRAS inhibitor-3 Inhibitor 99.65% Unkown
HY-137497 KRAS inhibitor-9 99.85% Unkown
HY-128522 ARS-1323-alkyne Inhibitor 99.59% Unkown
HY-132966 ASP2453 Inhibitor 98.04% Unkown
HY-144661 KRAS G12D inhibitor 14 99.39% Unkown
HY-139047 SW157765 Inhibitor 98.67% Unkown
HY-139186 PROTAC KRAS G12C degrader-1 99.55% Unkown
HY-P2265A SAH-SOS1A TFA Inhibitor 99.16% Unkown
HY-136265 BC-LI-0186 Inhibitor 98.85% Unkown
HY-146223 AZD4625 Inhibitor 99.52% Unkown
HY-N0735 Phellodendrine chloride 99.79% Unkown
HY-P3277 KRpep-2d Inhibitor 95.09% Unkown
HY-148273 Setidegrasib Inhibitor 99.65% Unkown
HY-151881 SOS1-IN-15 Inhibitor 99.51% Unkown
HY-142160 GNE-9815 Inhibitor 98.28% Unkown
HY-156671 RMC-4998 96.33% Unkown
HY-148278 BI-0474 Inhibitor 99.83% Unkown
HY-114491A Rineterkib hydrochloride Inhibitor 99.81% Unkown
HY-125872 KRAS G12C inhibitor 14 Inhibitor 98.07% Unkown
HY-128771 K-Ras G12C-IN-4 Inhibitor 98.60% Unkown
HY-147008 XP-524 Inhibitor 99.66% Unkown
HY-151517 SOS1-IN-14 Inhibitor 99.38% Unkown
HY-143589 Glecirasib Inhibitor / Unkown
HY-145737A PROTAC SOS1 degrader-1 TFA Agonist 99.38% Unkown
HY-15879 LB42708 ≥99.0% Unkown
HY-16662 Oncrasin-1 98.28% Unkown
HY-U00417 ARS-1630 Inhibitor 98.10% Unkown
HY-138295 KRAS inhibitor-10 Inhibitor 99.86% Unkown
HY-154959 AZD4747 Inhibitor 99.81% Unkown
HY-125873 KRAS G12C inhibitor 15 Inhibitor 99.55% Unkown
HY-112929B (1S,2S,3R)-DT-061 99.73% Unkown
HY-114398A (S)-BAY-293 / Unkown
HY-126247B (R)-BI-2852 97.32% Unkown
HY-130819 Tos-PEG4-THP ≥95.0% Unkown
HY-18604 K-Ras G12C-IN-1 Inhibitor 98.19% Unkown
HY-158107 BBO-8520 Inhibitor / Unkown
HY-U00416 ARS-1323 Inhibitor 99.14% Unkown
HY-160699 DCC-3116 Inhibitor / Unkown
HY-18606 K-Ras G12C-IN-3 Inhibitor 99.94% Unkown
HY-122641 Deltasonamide 1 Inhibitor 99.15% Unkown
HY-145615 Pomalidomide-C12-NH2 hydrochloride 97.09% Unkown
HY-153821 PROTAC KRAS G12C degrader-2 Degrader 98.45% Unkown
HY-154313 Spiclomazine Inhibitor 99.95% Unkown
HY-115489 GGTI-286 Inhibitor / Unkown
HY-157029S KRASG12D-IN-1 Inhibitor 98.07% Unkown
HY-115489A GGTI-286 TFA Inhibitor / Unkown
HY-142460 KRAS G12C inhibitor 28 Inhibitor 99.94% Unkown
HY-145962 MRTX-EX185 Inhibitor / Unkown
HY-128590 PHT-7.3 Inhibitor 98.50% Unkown
HY-130707 K-Ras ligand-Linker Conjugate 3 / Unkown
HY-130991 K-Ras ligand-Linker Conjugate 6 95.18% Unkown
HY-134811 KRAS G12D inhibitor 1 Inhibitor 98.45% Unkown
HY-161235 BTX-7312 Degrader / Unkown
HY-162431 MK-1084 Inhibitor / Unkown
HY-107720 ARL 17477 Inhibitor 99.02% Unkown
HY-112491 KRas G12C inhibitor 1 Inhibitor / Unkown
HY-117935 GGTI-286 hydrochloride Inhibitor / Unkown
HY-130820 THP-PEG4-Pyrrolidine(N-Boc)-CH2OH ≥95.0% Unkown
HY-130821 THP-PEG4-Pyrrolidine(N-Me)-CH2OH ≥95.0% Unkown
HY-134977 Atrovastatin-PEG3-FITC Inhibitor 98.17% Unkown
HY-136726 CGP-82996 Inhibitor / Unkown
HY-139612A (S)-JDQ-443 Inhibitor 99.32% Unkown
HY-153413 Kras4B G12D-IN-1 Inhibitor 98.01% Unkown
HY-162065 N6F11 Inducer 98.11% Unkown
HY-P3277A KRpep-2d TFA Inhibitor 98.11% Unkown
HY-W016889 CFL-137 Inhibitor 99.84% Unkown
HY-12446 K-Ras(G12C) inhibitor 9 Inhibitor ≥98.0% Unkown
HY-15747A Deltarasin hydrochloride Inhibitor 98.07% Unkown
HY-15872 FTI-277 / Unkown
HY-18605 K-Ras G12C-IN-2 Inhibitor 99.21% Unkown
HY-135864 KRAS inhibitor-6 Inhibitor / Unkown
HY-135865 KRAS inhibitor-7 Inhibitor / Unkown
HY-135866 KRAS inhibitor-8 Inhibitor / Unkown
HY-157031S KRASG12D-IN-2 Inhibitor 98.11% Unkown
HY-115880 KRAS G12D inhibitor 3 Inhibitor / Unkown
HY-129775 K-Ras ligand-Linker Conjugate 1 / Unkown
HY-129776 K-Ras ligand-Linker Conjugate 2 / Unkown
HY-132920 KRAS mutant protein inhibitor 1 Inhibitor / Unkown
HY-139894 KRAS G12D inhibitor 5 Inhibitor / Unkown
HY-142458 KRAS G12C inhibitor 27 Inhibitor / Unkown
HY-142487 KRAS G12C inhibitor 32 Inhibitor / Unkown
HY-108887 Anticancer agent 124 Inhibitor / Unkown
HY-114168 KRAS G12C inhibitor 5 Inhibitor / Unkown
HY-125874 KRAS G12C inhibitor 16 Inhibitor / Unkown
HY-125875 KRAS G12C inhibitor 17 Inhibitor / Unkown
HY-126292 KRAS G12C inhibitor 13 Inhibitor / Unkown
HY-130260 KRAS inhibitor-4 Inhibitor / Unkown
HY-130822 K-Ras ligand-Linker Conjugate 4 95.06% Unkown
HY-130823 K-Ras ligand-Linker Conjugate 5 96.96% Unkown
HY-132979 KRAS G12C inhibitor 18 Inhibitor / Unkown
HY-146544 KRAS inhibitor-14 Inhibitor / Unkown
HY-146546 KRAS inhibitor-16 Inhibitor / Unkown
HY-150926 G12Si-1 Inhibitor / Unkown
HY-150927 G12Si-2 Inhibitor / Unkown
HY-151287 KRAS inhibitor-20 Inhibitor / Unkown
HY-152848 Fulzerasib Inhibitor / Unkown
HY-153262 KRASG12C IN-2 Inhibitor / Unkown
HY-162249 ASP6918 Inhibitor / Unkown
HY-108436 Deltazinone 1 Inhibitor / Unkown
HY-112492 KRas G12C inhibitor 2 Inhibitor / Unkown
HY-112493 KRas G12C inhibitor 3 Inhibitor / Unkown
HY-112494 KRas G12C inhibitor 4 Inhibitor / Unkown
HY-114277S Sotorasib-d7 Inhibitor / Unkown
HY-114436S MRTX-1257-d6 / Unkown
HY-115880A KRAS G12D inhibitor 3 TFA Inhibitor / Unkown
HY-115907 K20 Inhibitor / Unkown
HY-122152 Spiclomazine hydrochloride Inhibitor / Unkown
HY-122641D Deltasonamide 1 TFA Inhibitor 99.70% Unkown
HY-124761 Poloppin Inhibitor / Unkown
HY-125335 Oligomycin D / Unkown
HY-13497 STK33-IN-1 Inhibitor / Unkown
HY-137516A LC-2 epimer / Unkown
HY-139402 MRTX849 acid Inhibitor 99.84% Unkown
HY-139403 MRTX849 ethoxypropanoic acid Antagonist / Unkown
HY-139910 KRAS G12D inhibitor 6 Inhibitor / Unkown
HY-139911 KRAS G12D inhibitor 7 Inhibitor / Unkown
HY-142457 KRAS G12C inhibitor 26 Inhibitor / Unkown
HY-142478 KRAS G12C inhibitor 29 Inhibitor / Unkown
HY-142481 KRAS G12C inhibitor 30 Inhibitor / Unkown
HY-142485 KRAS G12C inhibitor 31 Inhibitor / Unkown
HY-142490 KRAS G12C inhibitor 33 Inhibitor / Unkown
HY-142511 KRAS G12C inhibitor 34 Inhibitor / Unkown
HY-142945 KRAS G12C inhibitor 43 Inhibitor / Unkown
HY-142946 KRAS G12C inhibitor 44 Inhibitor / Unkown
HY-142947 KRAS G12C inhibitor 45 Inhibitor / Unkown
HY-142948 KRAS G12C inhibitor 46 Inhibitor / Unkown
HY-143359 COTI-219 Inhibitor / Unkown
HY-143588 KRAS G12C inhibitor 35 Inhibitor / Unkown
HY-143590 KRAS G12C inhibitor 37 Inhibitor / Unkown
HY-143591 KRAS G12C inhibitor 38 Inhibitor / Unkown
HY-143592 KRAS G12C inhibitor 39 Inhibitor / Unkown
HY-143594 KRAS G12C inhibitor 40 Inhibitor / Unkown
HY-143596 KRAS G12C inhibitor 41 Inhibitor / Unkown
HY-143598 KRAS G12C inhibitor 42 Inhibitor / Unkown
HY-143599 KRAS G12D inhibitor 8 Inhibitor / Unkown
HY-143602 KRAS G12D inhibitor 9 Inhibitor / Unkown
HY-143603 KRAS G12D inhibitor 10 Inhibitor / Unkown
HY-143604 KRAS G12D inhibitor 11 Inhibitor / Unkown
HY-143606 KRAS G12D inhibitor 12 Inhibitor / Unkown
HY-143607 KRAS G12D inhibitor 13 Inhibitor / Unkown
HY-144207 SOS1-IN-9 Inhibitor / Unkown
HY-144210 SOS1-IN-6 Inhibitor / Unkown
HY-144211 SOS1-IN-7 Inhibitor / Unkown
HY-144213 SOS1-IN-10 Inhibitor / Unkown
HY-144323 YF135 Inhibitor / Unkown
HY-144657 (4S)-PROTAC SOS1 degrader-1 Inhibitor / Unkown
HY-145017 KRAS G12C inhibitor 20 Inhibitor / Unkown
HY-145018 KRAS G12C inhibitor 21 Inhibitor / Unkown
HY-145019 KRAS G12C inhibitor 22 Inhibitor / Unkown
HY-145020 KRAS G12C inhibitor 23 Inhibitor / Unkown
HY-145022 KRAS G12C inhibitor 25 Inhibitor / Unkown
HY-145047 SOS1-IN-4 Inhibitor / Unkown
HY-145048 SOS1-IN-5 Inhibitor / Unkown
HY-145436 KRAS inhibitor-11 Inhibitor / Unkown
HY-145737 PROTAC SOS1 degrader-1 Agonist / Unkown
HY-146061 KRAS G12C inhibitor 48 Inhibitor / Unkown
HY-146223A (3R,10R,14aS)-AZD4625 / Unkown
HY-146243 TH-Z835 / Unkown
HY-146475 KRAS inhibitor-17 Inhibitor / Unkown
HY-146476 KRAS inhibitor-18 Inhibitor / Unkown
HY-146533 KRAS inhibitor-12 Inhibitor / Unkown
HY-146537 KRAS G12C inhibitor 47 Inhibitor / Unkown
HY-146543 KRAS inhibitor-13 Inhibitor / Unkown
HY-146545 KRAS inhibitor-15 Inhibitor / Unkown
HY-147595 KRAS G12D inhibitor 15 Inhibitor / Unkown
HY-147631 KRAS G12C inhibitor 50 Inhibitor / Unkown
HY-147632 KRAS G12C inhibitor 51 Inhibitor / Unkown
HY-147633 KRAS G12C inhibitor 52 Inhibitor / Unkown
HY-147634 KRAS G12C inhibitor 53 Inhibitor / Unkown
HY-147635 KRAS G12C inhibitor 54 Inhibitor / Unkown
HY-147636 KRAS G12C inhibitor 55 Inhibitor / Unkown
HY-148260 KRAS G12D inhibitor 16 Inhibitor / Unkown
HY-148261 KRAS G12C inhibitor 56 Inhibitor / Unkown
HY-149607 SHP2-IN-22 Inhibitor / Unkown
HY-149705 ICMT-IN-7 Inhibitor / Unkown
HY-149709 ICMT-IN-35 Inhibitor / Unkown
HY-151288 KRAS inhibitor-21 Inhibitor / Unkown
HY-15136B (Rac)-Lonafarnib / Unkown
HY-151571 ZG1077 Inhibitor / Unkown
HY-151968 KRAS G12C inhibitor 57 Inhibitor / Unkown
HY-151999 KRASG12C IN-1 Inhibitor / Unkown
HY-152145 PROTAC SOS1 degrader-3 / Unkown
HY-152248 ARS-2102 Inhibitor / Unkown
HY-153412 KRAS inhibitor-22 Degrader / Unkown
HY-153461 KRAS G12C inhibitor 58 Inhibitor / Unkown
HY-153555 KRAS G12D modulator-1 Modulator / Unkown
HY-153662 TH-Z816 Inhibitor / Unkown
HY-153663 TH-Z827 Inhibitor / Unkown
HY-153880 KRAS degrader-1 Degrader / Unkown
HY-153881 PROTAC KRAS G12C degrader-3 / Unkown
HY-153899 KRAS G12C inhibitor 59 Inhibitor / Unkown
HY-153940 SOS1/KRAS-IN-1 Inhibitor / Unkown
HY-153944 KRAS G12C inhibitor 60 Inhibitor / Unkown
HY-156363 K-Ras-IN-2 Inhibitor / Unkown
HY-156500 ICMT-IN-1 Inhibitor / Unkown
HY-156528 pan-KRAS-IN-4 Inhibitor / Unkown
HY-156529 pan-KRAS-IN-2 Inhibitor / Unkown
HY-156549 KRAS G12C inhibitor 61 Inhibitor / Unkown
HY-156555 pan-KRAS-IN-3 / Unkown
HY-157228 ACBI3 / Unkown
HY-157458 PDEδ autophagic degrader 1 / Unkown
HY-158008 (R)-G12Di-7 Inhibitor / Unkown
HY-161066 KRAS G13D-IN-1 Inhibitor / Unkown
HY-161173 PROTAC SOS1 degrader-5 / Unkown
HY-161176 PROTAC KRAS G12D degrader 1 Degrader / Unkown
HY-161177 PROTAC KRAS G12D degrader 2 Inhibitor / Unkown
HY-161233 BTX-6654 Inhibitor / Unkown
HY-161234 KRAS ligand 3 / Unkown
HY-161236 KRAS ligand 4 Inhibitor / Unkown
HY-161450 LHF418 Inhibitor / Unkown
HY-162112 KRB-456 Inhibitor / Unkown
HY-162281 PROTAC SOS1 degrader-6 Inhibitor / Unkown
HY-162321 ZINC57632462 Inhibitor / Unkown
HY-162366 KRAS G12D inhibitor 20 Inhibitor / Unkown
HY-162440 pan-KRAS-IN-7 Inhibitor / Unkown
HY-162441 pan-KRAS-IN-8 Inhibitor / Unkown
HY-162442 pan-KRAS-IN-9 Inhibitor / Unkown
HY-162443 pan-KRAS-IN-10 Inhibitor / Unkown
HY-162445 KRASG12D-IN-3 Inhibitor / Unkown
HY-162445S KRASG12D-IN-3-d3 / Unkown
HY-162446 pan-KRAS-IN-13 Inhibitor / Unkown
HY-163299 pan-KRAS-IN-5 / Unkown
HY-163488 pan-KRAS-IN-14 Inhibitor / Unkown
HY-N8387 Neogrifolin Inhibitor / Unkown
HY-P2265 SAH-SOS1A Inhibitor / Unkown
HY-RS07425 KRAS Human Pre-designed siRNA Set A / Unkown
HY-RS07426 Kras Mouse Pre-designed siRNA Set A / Unkown
HY-RS07427 Kras Rat Pre-designed siRNA Set A / Unkown
HY-W041315 CFL-120 Inhibitor ≥98.0% Unkown
HY-114277B Sotorasib isomer 99.09% Unkown
HY-144657A (4S)-PROTAC SOS1 degrader-1 diTFA Inhibitor 98.09% Unkown
HY-145928B Divarasib adipate Inhibitor / Unkown
HY-149710 POP-3MB Inhibitor / Unkown
HY-154959A (9R,12aR)-AZD4747 98.90% Unkown
HY-157067 KRAS G12C inhibitor 62 Inhibitor / Unkown
HY-160220S KRAS inhibitor-23 Inhibitor / Unkown
HY-160445 KRAS G12D inhibitor 19 / Unkown
HY-W335254 Deltarasin trihydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kras NCBI NCBI:3845