2. Gene
  3. Slc6a3 - solute carrier family 6 member 3 Gene

Slc6a3 - solute carrier family 6 member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Dat1

Gene ID: 24898 | Gene type: protein coding

About Slc6a3

Primary_assembly 1: 29,709,443-29,750,413 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 166 orthologues, 20 paralogues and is associated with 31 phenotypes. Biased expression in Brain (RPKM 15.2), Kidney (RPKM .8) and 1 other tissue.

Summary

Enables several functions, including amine binding activity; dopamine:sodium symporter activity; and Enzyme binding activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a3 Products(1)

mRNA Protein Name
NM_012694.2 NP_036826.1 sodium-dependent dopamine transporter

Slc6a3 Protein Structure

SLC6sbd_DAT1

SLC6sbd_DAT1: cd11514 (59 - 612)

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  • 619 a.a.
Protein Preferred Names Protein Names

sodium-dependent dopamine transporter

DA transporter

DAT

solute carrier family 6 (neurotransmitter transporter), member 3

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13308 SLC6A3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13309 Slc6a3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13310 Slc6a3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a3 NCBI NCBI:6531