FUCA2 - alpha-L-fucosidase 2 Gene

Homo sapiens

Also known as dJ20N2.5

Gene ID: 2519 | Gene type: protein coding

About FUCA2

Cytogenetic location: 6q24.2 Genomic coordinates (GRCh38): 6:143,494,812-143,511,720 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 24.8), colon (RPKM 24.3) and 25 other tissues.

Summary

This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This Enzyme is essential for Helicobacter pylori adhesion to human gastric Cancer cells. [provided by RefSeq, Aug 2010]

FUCA2 Products(1)

mRNA	Protein	Name
NM_032020.5	NP_114409.2	plasma alpha-L-fucosidase precursor

FUCA2 Protein Structure

Alpha_L_fucos

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

plasma alpha-L-fucosidase

I+/--L-fucosidase 2

Related Diseases

Diseases

Alias

Fucosidosis

Alpha-L-Fucosidase Deficiency	Fucosidase Deficiency Disease
A-Fucosidase Deficiency	Alpha Fucosidase Deficiency
Lysosomal Storage Disease Caused By Defective Alpha-L-Fucosidase With Accumulation Of Fucose In The Tissues	Alpha-Fucosidase Deficiency
Fucosidase Deficiency	FUCA1D

Laryngotracheitis

Angiokeratoma

Angiokeratoma Of Skin	Cutaneous Angiokeratoma
Skin Angiokeratoma

Skin Hemangioma

Angioma Of The Skin	Angiomatous Naevus Of Skin
Hemangioma Of Skin

Scheie Syndrome

Mucopolysaccharidosis Type Is	Alpha-L-Iduronidase Deficiency
Mucopolysaccharidosis Type I	Mucopolysaccharidosis I
Hurler-Scheie Syndrome	Mucopolysaccharidosis Type 1
Mucopolysaccharidosis Is	Mucopolysaccharidosis Type 1s
Mucopolysaccharidosis Type V	Hurler Syndrome
Idua Deficiency	Mps I
MPS1S	Mps1-S
Mucopolysaccharidosis Type V, Formerly	Mps V, Formerly
Mps5, Formerly	Lipochondrodystrophy
Mpsis	Mucopolysaccharidosis, Type I
Iduronidase Deficiency Disease	Mps I - Hurler Syndrome
Mucopolysaccharidosis, Mps-I	Mucopolysaccharidosis, Type 1
Attenuated Mps I	Mps 1
Scheie Syndrome Formerly Known As Mucopolysaccharidosis Type V)	Severe Mps I
Mps I H	Mps I H-S
Mps I S	Mps1
Mpsi	Mucopolysaccharidosis 1s
Mps Is	Mps-Is
Mps V	Mucopolysaccharidosis V
Pfaundler-Hurler Syndrome	L-Iduronidase Deficiency
Dysostosis Multiplex	Dysostosis Multiplex Syndrome
Gargoylism	Mps1 - [Mucopolysaccharidosis Type 1]

Hurler Syndrome

Mucopolysaccharidosis Ih	Mucopolysaccharidosis Type Ih
Mps1-H	MPS1H
Hurler Disease	Mpsih
Mucopolysaccharidosis Type 1h	Alpha-L-Iduronidase Deficiency
Dysostosis Multiplex	Dysostosis Multiplex Syndrome
Gargoylism	Hurler Disease Mps Type 1h
Hurler-Pfaundler Syndrome	L-Iduronidase Deficiency, Hurler Type
Mucopolysaccharidosis Type I Severe Form	Mucopolysaccharidosis 1h
Hurler'S Syndrome	Mps Ih
Mps-Ih	Pfaundler-Hurler Syndrome
Mucopolysaccharidosis I

Hurler-Scheie Syndrome

Mucopolysaccharidosis Type Ih/S	Mucopolysaccharidosis Ih/S
MPS1H/S	Mpsih/S
Mucopolysaccharidosis Type 1h/S	Mps1-Hs
Alpha-L-Iduronidase Deficiency	Mucopolysaccharidosis I
Mucopolysaccharidosis 1h/S	Mps-Ih/S

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05144	FUCA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FUCA2	RGD	RGD:1303053
Macaca mulatta	FUCA2	VGNC	VGNC:72827
Mus musculus	FUCA2	MGD	MGI:1914098
Bos taurus	FUCA2	VGNC	VGNC:29141
Felis catus	FUCA2	VGNC	VGNC:62388
Canis familiaris	FUCA2	VGNC	VGNC:53717

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