Adora2a - adenosine A2a receptor Gene

Rattus norvegicus

Also known as A2ar; ADENO; Adora2l1

Gene ID: 25369 | Gene type: protein coding

About Adora2a

Primary_assembly 20: 13,315,853-13,333,386 reverse strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 263 orthologues, 3 paralogues and is associated with 36 phenotypes. Biased expression in Brain (RPKM 73.9), Lung (RPKM 63.2) and 8 other tissues.

Summary

Enables G protein-coupled Adenosine Receptor activity; alpha-actinin binding activity; and type 5 metabotropic glutamate receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and regulation of secretion. Located in several cellular components, including axolemma; postsynaptic density; and synaptic membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with intermediate filament. Used to study lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora2a Products(2)

mRNA	Protein	Name
NM_053294.5	NP_445746.3	adenosine receptor A2a A2AR
NM_001357942.1	NP_001344871.1	adenosine receptor A2a uORF5

Adora2a Protein Structure

7tmA_Adenosine_R_A2A

0
100
200
300
410 a.a.

Protein Preferred Names

Protein Names

adenosine receptor A2a

Adenosine A2a-receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS00394	ADORA2A Human Pre-designed siRNA Set A	/	Unkown
HY-RS00395	Adora2a Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS00396	Adora2a Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adora2a	NCBI	NCBI:135

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