CNIH2 - cornichon family AMPA receptor auxiliary protein 2 Gene

Homo sapiens

Also known as Cnil; CNIH-2

Gene ID: 254263 | Gene type: protein coding

About CNIH2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,278,175-66,284,206 (from NCBI)

This gene has 6 transcripts (splice variants), 185 orthologues and 4 paralogues. Biased expression in brain (RPKM 22.4), adrenal (RPKM 2.7) and 1 other tissue.

Summary

The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

CNIH2 Products(1)

mRNA	Protein	Name
NM_182553.3	NP_872359.1	protein cornichon homolog 2

CNIH2 Protein Structure

Cornichon

0
100
160 a.a.

Protein Preferred Names

Protein Names

protein cornichon homolog 2

cornichon homolog 2

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02885	CNIH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CNIH2	RGD	RGD:1304930
Canis familiaris	CNIH2	VGNC	VGNC:39400
Felis catus	CNIH2	VGNC	VGNC:61016
Macaca mulatta	CNIH2	VGNC	VGNC:71366
Mus musculus	CNIH2	MGD	MGI:1277225
Bos taurus	CNIH2	VGNC	VGNC:106695

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