2. Gene
  3. Cd38 - CD38 molecule Gene

Cd38 - CD38 molecule Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ADPRC 1

Gene ID: 25668 | Gene type: protein coding

About Cd38

Primary_assembly 14: 67,172,063-67,211,986 reverse strand.mRatBN7.2:CM026987.1

This gene has 2 transcripts (splice variants), 281 orthologues, 1 paralogue and is associated with 8 phenotypes. Biased expression in Spleen (RPKM 249.7), Lung (RPKM 118.2) and 8 other tissues.

Summary

Enables NAD+ nucleosidase activity. Involved in several processes, including blood vessel diameter maintenance; long-term synaptic depression; and negative regulation of bone resorption. Located in basolateral plasma membrane; nucleus; and secretory granule membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human CD38 (CD38 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd38 Products(1)

mRNA Protein Name
NM_013127.2 NP_037259.1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Cd38 Protein Structure

Rib_hydrolayse

Rib_hydrolayse: pfam02267 (57 - 286)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

2'-phospho-ADP-ribosyl cyclase

2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

2'-phospho-cyclic-ADP-ribose transferase

ADP-ribosyl cyclase 1

CD38 antigen (ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase)

CD38H

cADPr hydrolase 1

cyclic ADP-ribose hydrolase 1

Recombinant Cd38 Proteins

Cat. No. Product Name Accession Purity
HY-P70077 CD38 Protein, Rat (HEK293, His) Q64244 (W45-V303) ≥95%
HY-P72897 CD38 Protein, Rat (HEK293, Fc) Q64244 (W45-V303) ≥95%

Related Agents

Approval
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9915 Daratumumab 98.90% Unkown
Clinical Phase
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P9915A Daratumumab (PBS) ≥95.0% Phase 4
HY-P9976A Isatuximab (anti-CD38) 98.44% Phase 3
HY-P99730 Mezagitamab Inhibitor 95.00% Phase 2
HY-P99616 Felzartamab Inhibitor 99.34% Phase 2
HY-P99744 Modakafusp alfa Inhibitor 96.22% Phase 2
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-123999 CD38 inhibitor 1 99.83% Unkown
HY-N0640 Kuromanin chloride Inhibitor 99.50% Unkown
HY-150508 MK-0159 Inhibitor 99.72% Unkown
HY-144987 RBN013209 98.87% Unkown
HY-129997 Luteolinidin chloride 99.14% Unkown
HY-134358A Ara-F-NAD+ sodium Inhibitor / Unkown
HY-144988 CD38 inhibitor 2 98.81% Unkown
HY-134358 Ara-F-NAD+ Inhibitor / Unkown
HY-156120 CD38 inhibitor 3 Inhibitor / Unkown
HY-119648A (E/Z)-CCR-11 Inhibitor 98.00% Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990037 Erzotabart Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd38 NCBI NCBI:952
Macaca fascicularis Cd38 NCBI NCBI:102126394
Mus musculus Cd38 NCBI NCBI:12494
Leporidae Cd38 NCBI