GLCE - glucuronic acid epimerase Gene

Homo sapiens

Also known as HSEPI

Gene ID: 26035 | Gene type: protein coding

About GLCE

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:69,160,635-69,272,207 (from NCBI)

This gene has 4 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in colon (RPKM 5.9), duodenum (RPKM 5.7) and 25 other tissues.

Summary

Enables calcium ion binding activity; heparosan-N-sulfate-glucuronate 5-epimerase activity; and protein homodimerization activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

GLCE Products(5)

mRNA	Protein	Name
NM_001324091.2	NP_001311020.1	D-glucuronyl C5-epimerase isoform 2
NM_001324092.2	NP_001311021.1	D-glucuronyl C5-epimerase isoform 3
NM_001324093.2	NP_001311022.1	D-glucuronyl C5-epimerase isoform 1
NM_001324094.2	NP_001311023.1	D-glucuronyl C5-epimerase isoform 1
NM_015554.3	NP_056369.1	D-glucuronyl C5-epimerase isoform 1

GLCE Protein Structure

C5-epim_C

0
100
200
300
400
500
617 a.a.

Protein Preferred Names

Protein Names

D-glucuronyl C5-epimerase

UDP-glucuronic acid epimerase

Related Diseases

Diseases

Alias

Triosephosphate Isomerase Deficiency

TPID	Triose Phosphate-Isomerase Deficiency
Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency	Tpi Deficiency
Triose Phosphate Isomerase Deficiency	Deficiency Of Phosphotriose Isomerase
Hereditary Nonspherocytic Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05467	GLCE Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GLCE	MGD	MGI:2136405
Rattus norvegicus	GLCE	RGD	RGD:1565253
Macaca mulatta	GLCE	VGNC	VGNC:72959
Canis familiaris	GLCE	VGNC	VGNC:41251
Bos taurus	GLCE	VGNC	VGNC:29394
Felis catus	GLCE	VGNC	VGNC:62573