2. Gene
  3. GCNT1 - glucosaminyl (N-acetyl) transferase 1 Gene

GCNT1 - glucosaminyl (N-acetyl) transferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as G6NT; C2GNT; C2GNT1; NACGT2; NAGCT2; C2GNT-L; C2GlcNAcT

Gene ID: 2650 | Gene type: protein coding

About GCNT1

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:76,441,666-76,507,416 (from NCBI)

This gene has 6 transcripts (splice variants), 150 orthologues and 8 paralogues. Biased expression in duodenum (RPKM 20.0), stomach (RPKM 13.9) and 13 other tissues.

Summary

This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this Enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GCNT1 Products(9)

mRNA Protein Name
NM_001097633.2 NP_001091102.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097634.1 NP_001091103.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097635.2 NP_001091104.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001097636.2 NP_001091105.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407181.1 NP_001394110.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407182.1 NP_001394111.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407183.1 NP_001394112.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001407184.1 NP_001394113.1 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
NM_001490.5 NP_001481.2 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

GCNT1 Protein Structure

Branch

Branch: Core-2/I-Branching enzyme (123 - 391)

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  • 428 a.a.
Protein Preferred Names Protein Names

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

beta-1,6-N-acetylglucosaminyltransferase

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05339 GCNT1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GCNT1 RGD RGD:621370
Canis familiaris GCNT1 VGNC VGNC:54843
Mus musculus GCNT1 MGD MGI:95676
Bos taurus GCNT1 VGNC VGNC:56968