2. Gene
  3. FILIP1 - filamin A interacting protein 1 Gene

FILIP1 - filamin A interacting protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FILIP

Gene ID: 27145 | Gene type: protein coding

About FILIP1

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:75,291,859-75,493,800 (from NCBI)

This gene has 4 transcripts (splice variants), 280 orthologues and 3 paralogues. Biased expression in heart (RPKM 16.2), esophagus (RPKM 4.3) and 12 other tissues.

Summary

This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016]

FILIP1 Products(3)

mRNA Protein Name
NM_001289987.3 NP_001276916.1 filamin-A-interacting protein 1 isoform 1
NM_001300866.3 NP_001287795.1 filamin-A-interacting protein 1 isoform 3
NM_015687.5 NP_056502.1 filamin-A-interacting protein 1 isoform 2

FILIP1 Protein Structure

CortBP2

CortBP2: Cortactin-binding protein-2 (66 - 257)

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  • 1213 a.a.
Protein Preferred Names Protein Names

filamin-A-interacting protein 1

Related Diseases

Diseases Alias
Glioblastoma Proneural Subtype
Cerebrooculofacioskeletal Syndrome 1

Cofs Syndrome

COFS1

Pena-Shokeir Syndrome Type 2

Cofs

Pena-Shokeir Syndrome, Type Ii

Cerebrooculofacioskeletal Syndrome

Cerebro-Oculo-Facio-Skeletal Syndrome 1

Pena Shokeir Syndrome Type 2
Periventricular Nodular Heterotopia

Periventricular Heterotopia

Pvnh

Familial Nodular Heterotopia

Heterotopia, Periventricular

Periventricular Heterotopia, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04948 FILIP1 Human Pre-designed siRNA Set A / Unkown
HY-RS04949 FILIP1L Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FILIP1 MGD MGI:1917848
Rattus norvegicus FILIP1 RGD RGD:628597
Felis catus FILIP1 VGNC VGNC:62273
Canis familiaris FILIP1 VGNC VGNC:40881
Bos taurus FILIP1 VGNC VGNC:29012
Macaca mulatta FILIP1 VGNC VGNC:72544