GATC - glutamyl-tRNA amidotransferase subunit C Gene

Homo sapiens

Also known as 15E1.2; COXPD42

Gene ID: 283459 | Gene type: protein coding

About GATC

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,446,444-120,463,749 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 15.5), lymph node (RPKM 14.0) and 25 other tissues.

Summary

Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined oxidative phosphorylation deficiency 42. [provided by Alliance of Genome Resources, Apr 2022]

GATC Products(1)

mRNA	Protein	Name
NM_176818.3	NP_789788.1	glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

GATC Protein Structure

Glu-tRNAGln

0
100
136 a.a.

Protein Preferred Names

Protein Names

glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

glu-AdT subunit C

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 42

COXPD42

Combined Oxidative Phosphorylation Deficiency

Wound Botulism

Cutaneous Infectious Botulism	Cutaneous Toxin-Mediated Botulism
Inoculation Botulism	Skin Infectious Botulism
Skin Toxin-Mediated Botulism

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148511	Vidutolimod	Agonist	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150741	ODN 2216		97.88%	Unkown
HY-RS05299	GATC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GATC	MGD	MGI:1923776
Rattus norvegicus	GATC	RGD	RGD:1309698

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