2. Gene
  3. GRK6 - G protein-coupled receptor kinase 6 Gene

GRK6 - G protein-coupled receptor kinase 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GPRK6

Gene ID: 2870 | Gene type: protein coding

About GRK6

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,425,523-177,442,891 (from NCBI)

This gene has 11 transcripts (splice variants), 209 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 27.2), lymph node (RPKM 19.5) and 23 other tissues.

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GRK6 Products(4)

mRNA Protein Name
NM_001004105.3 NP_001004105.1 G protein-coupled receptor kinase 6 isoform C
NM_001004106.3 NP_001004106.1 G protein-coupled receptor kinase 6 isoform A
NM_001364164.2 NP_001351093.1 G protein-coupled receptor kinase 6 isoform D
NM_002082.4 NP_002073.2 G protein-coupled receptor kinase 6 isoform B

GRK6 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (53 - 170)

Pkinase

Pkinase: Protein kinase domain (187 - 448)

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  • 576 a.a.
Protein Preferred Names Protein Names

G protein-coupled receptor kinase 6

Recombinant GRK6 Proteins

Cat. No. Product Name Accession Purity
HY-P75799 GRK6 Protein, Human (sf9, His-GST) P43250-2 (M1-R589) ≥95%

Related Diseases

Diseases Alias
Whim Syndrome 1

Whim Syndrome

Whims

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis

WHIMS1

Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1

Myelokathexis, Isolated

Wilm

Warts-Infections-Leukopenia-Myelokatexis Syndrome

Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-142812 GRK6-IN-1 99.64% Unkown
HY-142817 GRK6-IN-2 99.39% Unkown
HY-128311 GRK6-IN-3 Inhibitor / Unkown
HY-150021 GRK5-IN-3 Inhibitor / Unkown
HY-RS05817 GRK6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GRK6 VGNC VGNC:73268
Felis catus GRK6 VGNC VGNC:67449
Bos taurus GRK6 VGNC VGNC:29657
Mus musculus GRK6 MGD MGI:1347078
Rattus norvegicus GRK6 RGD RGD:61986
Canis familiaris GRK6 VGNC VGNC:41506
Others GRK6 NCBI