2. Gene
  3. GPX4 - glutathione peroxidase 4 Gene

GPX4 - glutathione peroxidase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MCSP; SMDS; GPx-4; PHGPx; snGPx; GSHPx-4; snPHGPx

Gene ID: 2879 | Gene type: protein coding

About GPX4

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,103,994-1,106,779 (from NCBI)

This gene has 11 transcripts (splice variants), 162 orthologues, 7 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 347.9), testis (RPKM 229.8) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the Glutathione Peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. [provided by RefSeq, Dec 2018]

GPX4 Products(4)

mRNA Protein Name
NM_001039847.3 NP_001034936.1 phospholipid hydroperoxide glutathione peroxidase isoform B precursor
NM_001039848.4 NP_001034937.1 phospholipid hydroperoxide glutathione peroxidase isoform C
NM_001367832.1 NP_001354761.1 phospholipid hydroperoxide glutathione peroxidase isoform D
NM_002085.5 NP_002076.2 phospholipid hydroperoxide glutathione peroxidase isoform A precursor

GPX4 Protein Structure

GSHPx

GSHPx: Glutathione peroxidase (41 - 148)

  • 0
  • 100
  • 197 a.a.
Protein Preferred Names Protein Names

phospholipid hydroperoxide glutathione peroxidase

epididymis secretory sperm binding protein

Related Diseases

Diseases Alias
Spondylometaphyseal Dysplasia, Sedaghatian Type

SMDS

Sedaghatian Chondrodysplasia

Spondylometaphyseal Dysplasia Sedaghatian Type

Congenital Lethal Metaphyseal Chondrodysplasia

Metaphyseal Chondrodysplasia, Congenital Lethal

Lethal Metaphyseal Dysplasia
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Pontocerebellar Hypoplasia, Type 2d

Pontocerebellar Hypoplasia Type 2d

Pcca

PCH2D

Progressive Cerebello-Cerebral Atrophy

Cerebellocerebral Atrophy, Progressive

Pontocerebellar Hypoplasia 2d

Progressive Cerebellocerebral Atrophy

Hypoplasia, Pontocerebellar, Type 2d
Gum Cancer

Malignant Neoplasm Of Gum

Malignant Tumor Of Gum

Malignant Gingival Tumor

Malignant Neoplasm Of Other Sites Of Gum

Malignant Tumour Of Gingiva
Infertility
Encephalomalacia
Periventricular Leukomalacia

Leukomalacia, Periventricular

Pvl

Leukomalacia Periventricular
Spondyloepimetaphyseal Dysplasia, Strudwick Type

Spondylometaphyseal Dysplasia

Strudwick Syndrome

Dappled Metaphysis Syndrome

Semd, Strudwick Type

Spondylometaepiphyseal Dysplasia Congenita, Strudwick Type

Smed, Strudwick Type

Smd

Smed Strudwick Type

SEMDSTWK

Smed, Type I

Semdc

Smed Type 1

Spondyloepimetaphyseal Dysplasia Strudwick Type

Sed Strudwick

Spondyloepimetaphyseal Dysplasia Congenita, Strudwick Type

Smed Type I

Spondyloepiphyseal Dysplasia Congenita With Dappled Metaphyses

Dysplasia, Spondyloepimetaphyseal, Strudwick Type

Dysplasia, Spondylometaphyseal
Fanconi Anemia, Complementation Group D2

Fanconi Anemia Complementation Group D2

FANCD2

Fad2

Fa4

Fancd

Fanconi Pancytopenia Type 4

Fanconi Anemia, Complementation Group D

Fanconi Pancytopenia, Type 4

Facd

Fanconi Anemia Complementation Group D
Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0774 Seratrodast 98.86% Unkown
Pre-clinical Phase
Bioactive Molecules (38)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100218A RSL3 99.90% Unkown
HY-136057 iFSP1 Activator 99.89% Unkown
HY-103087 FIN56 Activator 98.28% Unkown
HY-100003 ML-210 99.89 Unkown
HY-100002 ML162 99.35% Unkown
HY-129457 FINO2 Activator ≥98.0% Unkown
HY-138153 JKE-1674 98.30% Unkown
HY-141809 GPX4-IN-3 99.90% Unkown
HY-N0070 Solasonine 99.19% Unkown
HY-115627 PKUMDL-LC-101-D04 Activator 99.43% Unkown
HY-120912 Gingerenone A Activator 99.49% Unkown
HY-157068 icFSP1 Inhibitor 99.72% Unkown
HY-155663 GPX4-IN-5 99.35% Unkown
HY-149236 PROTAC GPX4 degrader-1 99.35% Unkown
HY-153748 ML162-yne 99.23% Unkown
HY-162065 N6F11 Inducer 98.11% Unkown
HY-100218C (1R,3R)-RSL3 99.52% Unkown
HY-139001 JKE-1716 ≥98.0% Unkown
HY-155664 GPX4-IN-6 / Unkown
HY-138556 GPX4-IN-2 Inhibitor 98.66% Unkown
HY-149455 GPX4-IN-8 Inhibitor / Unkown
HY-149923 GPX4-IN-4 Inhibitor / Unkown
HY-151212 BCP-T.A Inducer / Unkown
HY-151428 Antitumor agent-78 / Unkown
HY-151429 Antitumor agent-77 / Unkown
HY-155075 NC-R17 Inhibitor / Unkown
HY-155203 Anticancer agent 154 Inducer / Unkown
HY-155851 Lepadin E / Unkown
HY-155852 Lepadin H Inducer / Unkown
HY-156286 GPX4-IN-7 Inducer / Unkown
HY-157762 GPX4-IN-9 / Unkown
HY-157788 ZX703 / Unkown
HY-161075 Microtubule inhibitor 8 / Unkown
HY-161460 Ferroptosis-IN-7 Inhibitor / Unkown
HY-162106 PROTAC GPX4 degrader-2 / Unkown
HY-163272 GPX4/CDK-IN-1 Inhibitor / Unkown
HY-RS05767 GPX4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-P3284 Mastoparan M tetraacetate Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GPX4 MGD MGI:104767
Rattus norvegicus GPX4 RGD RGD:69226
Bos taurus GPX4 VGNC VGNC:106759
Felis catus GPX4 VGNC VGNC:80055