2. Gene
  3. DDX25 - DEAD-box helicase 25 Gene

DDX25 - DEAD-box helicase 25 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GRTH

Gene ID: 29118 | Gene type: protein coding

About DDX25

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,903,328-125,928,843 (from NCBI)

This gene has 10 transcripts (splice variants), 131 orthologues and 38 paralogues. Restricted expression toward testis (RPKM 40.9).

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]

DDX25 Products(2)

mRNA Protein Name
NM_001330438.2 NP_001317367.1 ATP-dependent RNA helicase DDX25 isoform 2
NM_013264.5 NP_037396.3 ATP-dependent RNA helicase DDX25 isoform 1

DDX25 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (122 - 284)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (359 - 439)

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  • 483 a.a.
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DDX25

DEAD (Asp-Glu-Ala-Asp) box helicase 25

Related Diseases

Diseases Alias
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03640 DDX25 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DDX25 RGD RGD:68381
Macaca mulatta DDX25 VGNC VGNC:71666
Canis familiaris DDX25 VGNC VGNC:39852
Mus musculus DDX25 MGD MGI:1353582
Felis catus DDX25 VGNC VGNC:61403
Bos taurus DDX25 VGNC VGNC:27961