2. Gene
  3. Pak1 - p21 (RAC1) activated kinase 1 Gene

Pak1 - p21 (RAC1) activated kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 29431 | Gene type: protein coding

About Pak1

Primary_assembly 1: 152,111,188-152,226,383 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 216 orthologues, 36 paralogues and is associated with 20 phenotypes. Biased expression in Brain (RPKM 564.9), Adrenal (RPKM 131.3) and 7 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; nervous system development; and positive regulation of cell migration. Located in several cellular components, including Z disc; intercalated disc; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pak1 Products(1)

mRNA Protein Name
NM_017198.2 NP_058894.1 serine/threonine-protein kinase PAK 1

Pak1 Protein Structure

PBD

PBD: pfam00786 (73 - 131)

STKc_PAK1

STKc_PAK1: cd06654 (247 - 542)

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  • 544 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 1

PAK-1

alpha-PAK

p21 (CDKN1A)-activated kinase 1

p21 protein (Cdc42/Rac)-activated kinase 1

p21-activated kinase 1

p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)

p68-PAK

protein kinase MUK2

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12005 Fingolimod hydrochloride Activator 99.95% Yes
HY-15027 5-Aminosalicylic Acid Inhibitor ≥98.0% Unkown
HY-11063 Fingolimod Activator 99.56% Yes
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13007 PF-3758309 Inhibitor 99.84% Phase 1
Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15663 IPA-3 Inhibitor 99.43% Unkown
HY-15542A FRAX597 Inhibitor 99.79% Unkown
HY-15542B FRAX486 Inhibitor 98.01% Unkown
HY-19635 G-5555 Inhibitor 99.29% Unkown
HY-19538 FRAX1036 Inhibitor 98.88% Unkown
HY-19635A G-5555 hydrochloride Inhibitor 98.78% Unkown
HY-120940 AZ13705339 Inhibitor 98.90% Unkown
HY-120940A AZ13705339 hemihydrate Inhibitor 99.77% Unkown
HY-131265 Mesalamine impurity P Inhibitor / Unkown
HY-110085 2,2′-Dihydroxy-6,6′-dinaphthyl disulfide Inhibitor / Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-146786 ZMF-10 Inhibitor / Unkown
HY-146783 ZINC194100678 Inhibitor / Unkown
HY-146681 PAK1-IN-1 Inhibitor / Unkown
HY-131043 NVS-PAK1-C Inhibitor ≥99.0% Unkown
HY-116917 G-9791 Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pak1 NCBI NCBI:5058