2. Gene
  3. CPSF1 - cleavage and polyadenylation specific factor 1 Gene

CPSF1 - cleavage and polyadenylation specific factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MYP27; CPSF160; P/cl.18; HSU37012

Gene ID: 29894 | Gene type: protein coding

About CPSF1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,393,231-144,409,335 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 197 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 31.8), duodenum (RPKM 25.9) and 25 other tissues.

Summary

Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

CPSF1 Products(1)

mRNA Protein Name
NM_013291.3 NP_037423.2 cleavage and polyadenylation specificity factor subunit 1

CPSF1 Protein Structure

MMS1_N

MMS1_N: Mono-functional DNA-alkylating methyl methanesulfonate N-term (92 - 671)

CPSF_A

CPSF_A: CPSF A subunit region (1073 - 1408)

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  • 1443 a.a.
Protein Preferred Names Protein Names

cleavage and polyadenylation specificity factor subunit 1

CPSF 160 kDa subunit

Related Diseases

Diseases Alias
Myopia 27, Autosomal Dominant

Myopia 27

MYP27
Refractive Error

Refractive Errors
Myopia

Near-Sightedness

Short-Sightedness

Nearsightedness

Nearsighted

Near Vision

Close Sighted

Myopic

Short-Sighted

Near Sighted
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03116 CPSF1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CPSF1 VGNC VGNC:39573
Rattus norvegicus CPSF1 RGD RGD:1306406
Macaca mulatta CPSF1 VGNC VGNC:71472
Bos taurus CPSF1 VGNC VGNC:27670
Felis catus CPSF1 VGNC VGNC:82368
Mus musculus CPSF1 MGD MGI:2679722