RORA - RAR-related orphan receptor A Gene

Rattus norvegicus

Gene ID: 300807 | Gene type: protein coding

About RORA

Primary_assembly 8: 69,301,733-70,025,931 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 395 orthologues, 19 paralogues and is associated with 8 phenotypes. Biased expression in Adrenal (RPKM 181.6), Muscle (RPKM 18.7) and 9 other tissues.

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

RORA Products(3)

mRNA	Protein	Name
XM_008766410.3	XP_008764632.1	nuclear receptor ROR-alpha isoform X3
XM_039082823.1	XP_038938751.1	nuclear receptor ROR-alpha isoform X1
XM_039082824.1	XP_038938752.1	nuclear receptor ROR-alpha isoform X2

RORA Protein Structure

NR_DBD_ROR

NR_LBD_ROR_like

0
100
200
300
400
523 a.a.

Protein Preferred Names

Protein Names

nuclear receptor ROR-alpha

RAR-related orphan receptor alpha

nuclear receptor ROR-alpha-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12126	RORA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12127	Rora Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12128	RORA Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	RORA	NCBI	NCBI:6095

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