Myd88 - MYD88, innate immune signal transduction adaptor Gene

Rattus norvegicus

Gene ID: 301059 | Gene type: protein coding

About Myd88

Primary_assembly 8: 119,074,437-119,079,415 reverse strand.mRatBN7.2:CM026981.1

This gene has 4 transcripts (splice variants), 200 orthologues and is associated with 61 phenotypes. Biased expression in Spleen (RPKM 125.3), Thymus (RPKM 16.6) and 9 other tissues.

Summary

Enables Toll binding activity and interleukin-1 receptor binding activity. Involved in JNK cascade; cell surface receptor signaling pathway; and positive regulation of smooth muscle cell proliferation. Located in postsynaptic density. Part of protein-containing complex. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia; colorectal carcinoma; and primary immunodeficiency disease. Orthologous to human MyD88 (MyD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Apr 2022]

Myd88 Products(1)

mRNA	Protein	Name
NM_198130.2	NP_937763.2	myeloid differentiation primary response protein MyD88

Myd88 Protein Structure

Death_MyD88

TIR

0
100
200
296 a.a.

Protein Preferred Names

Protein Names

myeloid differentiation primary response protein MyD88

myeloid differentiation primary response 88

myeloid differentiation primary response gene 88

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139397	TJ-M2010-5	Inhibitor	99.25%	Unkown
HY-50937	ST 2825	Inhibitor	99.42%	Unkown
HY-110204	Heclin		99.80%	Unkown
HY-19744	T6167923	Inhibitor	99.08%	Unkown
HY-N0703	Schaftoside	Inhibitor	99.67%	Unkown
HY-110195	Smurf1-IN-A01		99.90%	Unkown
HY-149992	MyD88-IN-1	Inhibitor	99.95%	Unkown
HY-18976	UF010		99.84%	Unkown
HY-W011400	TLR1		≥99.0%	Unkown
HY-W014223	2,4′-Dihydroxybenzophenone	Inhibitor	/	Unkown
HY-Y0278	Chloranil	Inducer	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myd88	NCBI	NCBI:4615

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