2. Gene
  3. ANXA4 - annexin A4 Gene

ANXA4 - annexin A4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ANX4; P32.5; PIG28; PP4-X; ZAP36; PAP-II; HEL-S-274

Gene ID: 307 | Gene type: protein coding

About ANXA4

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:69,643,808-69,827,112 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 12 paralogues. Broad expression in gall bladder (RPKM 187.6), duodenum (RPKM 64.1) and 17 other tissues.

Summary

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits Phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

ANXA4 Products(5)

mRNA Protein Name
NM_001153.5 NP_001144.1 annexin A4 isoform a
NM_001320698.2 NP_001307627.1 annexin A4 isoform a
NM_001320700.2 NP_001307629.1 annexin A4 isoform b
NM_001320702.2 NP_001307631.1 annexin A4 isoform c
NM_001365496.2 NP_001352425.1 annexin A4 isoform a

ANXA4 Protein Structure

Annexin

Annexin: Annexin (20 - 83)

Annexin

Annexin: Annexin (92 - 157)

Annexin

Annexin: Annexin (175 - 241)

Annexin

Annexin: Annexin (251 - 316)

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  • 300
  • 321 a.a.
Protein Preferred Names Protein Names

annexin A4

35-beta calcimedin

Recombinant ANXA4 Proteins

Cat. No. Product Name Accession Purity
HY-P79388 Annexin A4 Protein, Human (His) NP_001144 (A2-D321) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00764 ANXA4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ANXA4 VGNC VGNC:37941
Macaca mulatta ANXA4 VGNC VGNC:69949
Mus musculus ANXA4 MGD MGI:88030
Bos taurus ANXA4 VGNC VGNC:25966
Felis catus ANXA4 VGNC VGNC:79989
Rattus norvegicus ANXA4 RGD RGD:621171
Others ANXA4 NCBI