S1pr4 - sphingosine-1-phosphate receptor 4 Gene

Rattus norvegicus

Also known as Edg6

Gene ID: 314649 | Gene type: protein coding

About S1pr4

Primary_assembly 7: 8,208,098-8,211,893 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 176 orthologues, 18 paralogues and is associated with 2 phenotypes.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human S1PR4 (sphingosine-1-phosphate receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

S1pr4 Products(1)

mRNA	Protein	Name
NM_001108075.1	NP_001101545.1	sphingosine 1-phosphate receptor 4

S1pr4 Protein Structure

7tm_GPCRs

0
100
200
300
413 a.a.

Protein Preferred Names

Protein Names

sphingosine 1-phosphate receptor 4

endothelial differentiation, G-protein-coupled receptor 6

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12355	Siponimod	Agonist	98.88%	Yes
HY-10569	Ponesimod	Agonist	99.81%	Yes
HY-12355A	Siponimod hemifumarate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17606	Cenerimod	Agonist	99.43%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136462	CYM50358	Antagonist	98.04%	Unkown
HY-116146	CYM50179	Agonist	95.01%	Unkown
HY-111253	CYM-5478	Agonist	99.90%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S1pr4	NCBI	NCBI:8698

Name
Email *

	Sorry, but the email address you supplied was invalid.