Mdm2 - MDM2 proto-oncogene Gene

Rattus norvegicus

Gene ID: 314856 | Gene type: protein coding

About Mdm2

Primary_assembly 7: 53,290,664-53,314,915 reverse strand.mRatBN7.2:CM026980.1

This gene has 4 transcripts (splice variants), 247 orthologues, 1 paralogue and is associated with 41 phenotypes. Biased expression in Testes (RPKM 24.7), Muscle (RPKM 22.2) and 9 other tissues.

Summary

Enables p53 binding activity; signaling receptor binding activity; and ubiquitin protein ligase activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of proteolysis; and response to alkaloid. Located in several cellular components, including cytosol; nucleus; and synapse. Used to study ichthyosis; post-traumatic stress disorder; and transient cerebral ischemia. Biomarker of breast cancer; intermittent claudication; liver disease; pancreatitis; and priapism. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; glioblastoma; hepatocellular carcinoma; pancreatic ductal carcinoma; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Mdm2 Products(1)

mRNA	Protein	Name
NM_001108099.1	NP_001101569.1	E3 ubiquitin-protein ligase Mdm2

Mdm2 Protein Structure

MDM2

zf-RanBP

mRING-HC-C2H2C4_MDM2

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532 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase Mdm2

MDM2 oncogene, E3 ubiquitin protein ligase	MDM2 proto-oncogene, E3 ubiquitin protein ligase
Mdm2 p53 binding protein homolog	double minute 2
p53 E3 ubiquitin protein ligase	transformed mouse 3T3 cell double minute 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128837	Nutlin carboxylic acid		98.36%	Unkown
HY-128836	(4R,5S)-Nutlin carboxylic acid		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mdm2	NCBI	NCBI:4193

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