2. Gene
  3. Pikfyve - phosphoinositide kinase, FYVE-type zinc finger containing Gene

Pikfyve - phosphoinositide kinase, FYVE-type zinc finger containing Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Pip5k3

Gene ID: 316457 | Gene type: protein coding

About Pikfyve

Primary_assembly 9: 66,563,727-66,657,868 forward strand.mRatBN7.2:CM026982.1

This gene has 4 transcripts (splice variants), 205 orthologues, 17 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 173.2), Spleen (RPKM 145.9) and 9 other tissues.

Summary

Predicted to enable phosphotransferase activity, alcohol group as acceptor and zinc ion binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; phosphatidylinositol metabolic process; and vesicle organization. Predicted to act upstream of or within myelin assembly. Predicted to be located in several cellular components, including cytoplasmic vesicle membrane; membrane raft; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKfyve (phosphoinositide kinase, FYVE-type zinc finger containing). [provided by Alliance of Genome Resources, Apr 2022]

Pikfyve Products(11)

mRNA Protein Name
XM_006245073.2 XP_006245135.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X3
XM_006245077.4 XP_006245139.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4
XM_039084597.1 XP_038940525.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X8
XM_006245076.4 XP_006245138.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4
XM_039084596.1 XP_038940524.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X5
XM_006245071.2 XP_006245133.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1
XM_006245074.4 XP_006245136.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4
XM_006245079.2 XP_006245141.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X7
XM_006245078.2 XP_006245140.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X6
XM_006245072.2 XP_006245134.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X2
XM_039084595.1 XP_038940523.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

Pikfyve Protein Structure

FYVE_PIKfyve_Fab1

FYVE_PIKfyve_Fab1: cd15725 (185 - 246)

DEP_PIKfyve

DEP_PIKfyve: cd04448 (388 - 469)

Fab1_TCP

Fab1_TCP: cd03334 (648 - 908)

PIPKc_PIKfyve

PIPKc_PIKfyve: cd17300 (1848 - 2114)

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  • 2129 a.a.
Protein Preferred Names Protein Names

1-phosphatidylinositol-3-phosphate 5-kinase

1-phosphatidylinositol 3-phosphate 5-kinase

phosphatidylinositol-3-phosphate 5-kinase type III

phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III

phosphoinositide kinase, FYVE finger containing

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-14644 Apilimod Inhibitor 99.56% Phase 2
HY-14644A Apilimod mesylate Inhibitor 99.83% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13228 YM-201636 Inhibitor 98.06% Unkown
HY-118630 Vacuolin-1 Inhibitor 98.93% Unkown
HY-15982 APY0201 Inhibitor 99.93% Unkown
HY-119624 MOMIPP Inhibitor 99.37% Unkown
HY-155994 PIK5-12d Degrader 99.90% Unkown
HY-151473 PIKfyve-IN-1 Inhibitor 99.64% Unkown
HY-163133 PIKfyve-IN-3 99.55% Unkown
HY-160477 DC-SX029 Inhibitor / Unkown
HY-154956 PIKfyve-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pikfyve NCBI NCBI:200576