2. Gene
  3. Porcn - porcupine O-acyltransferase Gene

Porcn - porcupine O-acyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1564947

Gene ID: 317368 | Gene type: protein coding

About Porcn

Primary_assembly X: 14,285,871-14,298,481 forward strand.mRatBN7.2:CM026994.1

This gene has 5 transcripts (splice variants), 268 orthologues, 5 paralogues and is associated with 5 phenotypes. Biased expression in Brain (RPKM 86.4), Lung (RPKM 36.5) and 9 other tissues.

Summary

Predicted to enable Wnt-protein binding activity and palmitoleoyltransferase activity. Predicted to be involved in several processes, including Wnt protein secretion; protein lipidation; and regulation of postsynaptic membrane neurotransmitter receptor levels. Predicted to act upstream of or within glycoprotein metabolic process. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in endoplasmic reticulum; glutamatergic synapse; and membrane. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to human PORCN (Porcupine O-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Porcn Products(1)

mRNA Protein Name
NM_001173355.1 NP_001166826.1 protein-serine O-palmitoleoyltransferase porcupine

Porcn Protein Structure

MBOAT

MBOAT: cl00738 (30 - 342)

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  • 461 a.a.
Protein Preferred Names Protein Names

protein-serine O-palmitoleoyltransferase porcupine

porcupine homolog

protein-cysteine N-palmitoyltransferase porcupine

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-17545 LGK974 Inhibitor 99.92% Phase 2
HY-18988 ETC-159 Inhibitor 98.96% Phase 1
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13912 IWP-2 Inhibitor 99.51% Unkown
HY-15659 Wnt-C59 Inhibitor 99.86% Unkown
HY-15825 IWP L6 Inhibitor 99.50% Unkown
HY-100853 IWP-O1 Inhibitor 99.61% Unkown
HY-100536 IWP-3 Inhibitor 98.23% Unkown
HY-111472 Porcn-IN-1 Inhibitor 99.92% Unkown
HY-107570 IWP-12 Inhibitor ≥99.0% Unkown
HY-13912G IWP-2 (GMP) Inhibitor / Unkown
HY-15659G Wnt-C59 (GMP) Inhibitor / Unkown
HY-156551 Porcn-IN-2 Inhibitor / Unkown
HY-RS10881 PORCN Human Pre-designed siRNA Set A / Unkown
HY-RS10882 Porcn Mouse Pre-designed siRNA Set A / Unkown
HY-RS10883 Porcn Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Porcn NCBI NCBI:64840