2. Gene
  3. APLP2 - amyloid beta precursor like protein 2 Gene

APLP2 - amyloid beta precursor like protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APPH; APPL2; CDEBP; APLP-2

Gene ID: 334 | Gene type: protein coding

About APLP2

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:130,069,894-130,144,805 (from NCBI)

This gene has 26 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 347.8), lung (RPKM 236.7) and 24 other tissues.

Summary

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

APLP2 Products(30)

mRNA Protein Name
NM_001142276.2 NP_001135748.1 amyloid beta precursor like protein 2 isoform 2 precursor
NM_001142277.2 NP_001135749.1 amyloid beta precursor like protein 2 isoform 3
NM_001142278.2 NP_001135750.1 amyloid beta precursor like protein 2 isoform 4 precursor
NM_001243299.2 NP_001230228.1 amyloid beta precursor like protein 2 isoform 5
NM_001328682.2 NP_001315611.1 amyloid beta precursor like protein 2 isoform 6 precursor
NM_001328684.2 NP_001315613.1 amyloid beta precursor like protein 2 isoform 7 precursor
NM_001328685.2 NP_001315614.1 amyloid beta precursor like protein 2 isoform 8 precursor
NM_001328686.2 NP_001315615.1 amyloid beta precursor like protein 2 isoform 9 precursor
NM_001382526.1 NP_001369455.1 amyloid beta precursor like protein 2 isoform 10 precursor
NM_001382527.1 NP_001369456.1 amyloid beta precursor like protein 2 isoform 11 precursor
NM_001382528.1 NP_001369457.1 amyloid beta precursor like protein 2 isoform 12
NM_001382529.1 NP_001369458.1 amyloid beta precursor like protein 2 isoform 13 precursor
NM_001382530.1 NP_001369459.1 amyloid beta precursor like protein 2 isoform 14
NM_001382531.1 NP_001369460.1 amyloid beta precursor like protein 2 isoform 15
NM_001382532.1 NP_001369461.1 amyloid beta precursor like protein 2 isoform 16
NM_001382533.1 NP_001369462.1 amyloid beta precursor like protein 2 isoform 17
NM_001382534.1 NP_001369463.1 amyloid beta precursor like protein 2 isoform 18
NM_001382535.1 NP_001369464.1 amyloid beta precursor like protein 2 isoform 19
NM_001382536.1 NP_001369465.1 amyloid beta precursor like protein 2 isoform 20
NM_001382537.1 NP_001369466.1 amyloid beta precursor like protein 2 isoform 21
NM_001382538.1 NP_001369467.1 amyloid beta precursor like protein 2 isoform 22 precursor
NM_001382539.1 NP_001369468.1 amyloid beta precursor like protein 2 isoform 23
NM_001382540.1 NP_001369469.1 amyloid beta precursor like protein 2 isoform 24
NM_001382541.1 NP_001369470.1 amyloid beta precursor like protein 2 isoform 25
NM_001382542.1 NP_001369471.1 amyloid beta precursor like protein 2 isoform 26
NM_001382543.1 NP_001369472.1 amyloid beta precursor like protein 2 isoform 27
NM_001382544.1 NP_001369473.1 amyloid beta precursor like protein 2 isoform 28
NM_001382545.1 NP_001369474.1 amyloid beta precursor like protein 2 isoform 29
NM_001382546.1 NP_001369475.1 amyloid beta precursor like protein 2 isoform 30 precursor
NM_001642.3 NP_001633.1 amyloid beta precursor like protein 2 isoform 1 precursor

APLP2 Protein Structure

APP_N

APP_N: Amyloid A4 N-terminal heparin-binding (49 - 147)

APP_Cu_bd

APP_Cu_bd: Copper-binding of amyloid precursor, CuBD (148 - 205)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (309 - 361)

APP_E2

APP_E2: E2 domain of amyloid precursor protein (365 - 548)

APP_amyloid

APP_amyloid: beta-amyloid precursor protein C-terminus (708 - 759)

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  • 763 a.a.
Protein Preferred Names Protein Names

amyloid beta precursor like protein 2

CDEI box-binding protein

Recombinant APLP2 Proteins

Cat. No. Product Name Accession Purity
HY-P700659 APLP-2 Protein, Human (HEK293, His) Q06481-1 (G32-S692) ≥95%

Related Diseases

Diseases Alias
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
Myopia

Near-Sightedness

Short-Sightedness

Nearsightedness

Nearsighted

Near Vision

Close Sighted

Myopic

Short-Sighted

Near Sighted
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00827 APLP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris APLP2 VGNC VGNC:37989
Felis catus APLP2 VGNC VGNC:67762
Rattus norvegicus APLP2 RGD RGD:2128
Mus musculus APLP2 MGD MGI:88047
Bos taurus APLP2 VGNC VGNC:26020
Macaca mulatta APLP2 VGNC VGNC:69984