2. Gene
  3. Prmt5 - protein arginine methyltransferase 5 Gene

Prmt5 - protein arginine methyltransferase 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Skb1; Hrmt1l5

Gene ID: 364382 | Gene type: protein coding

About Prmt5

Primary_assembly 15: 27,968,910-27,978,296 reverse strand.mRatBN7.2:CM026988.1

This gene has 3 transcripts (splice variants), 200 orthologues and is associated with 9 phenotypes. Biased expression in Kidney (RPKM 128.5), Brain (RPKM 19.8) and 9 other tissues.

Summary

Predicted to enable several functions, including p53 binding activity; protein-arginine N-methyltransferase activity; and sequence-specific DNA binding activity. Involved in several processes, including liver regeneration; positive regulation of oligodendrocyte differentiation; and regulation of ERK1 and ERK2 cascade. Part of protein-containing complex. Biomarker of asthma. Orthologous to human PRMT5 (protein arginine methyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]

Prmt5 Products(1)

mRNA Protein Name
NM_001108867.2 NP_001102337.2 protein arginine N-methyltransferase 5

Prmt5 Protein Structure

PRMT5_TIM

PRMT5_TIM: pfam17285 (36 - 289)

PRMT5

PRMT5: pfam05185 (294 - 463)

PRMT5_C

PRMT5_C: pfam17286 (467 - 634)

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  • 637 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 5

HMT1 hnRNP methyltransferase-like 5

SKB1 homolog

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-101563 GSK3326595 Inhibitor 99.97% Phase 2
HY-139611 MRTX-1719 Inhibitor 99.40% Phase 2
HY-148419 TNG908 Inhibitor 98.89% Phase 2
HY-101564 Onametostat Inhibitor 99.79% Phase 1
HY-131493 PF-06939999 Inhibitor 99.69% Phase 1
Pre-clinical Phase
Bioactive Molecules (23)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100235 GSK591 Inhibitor 99.91% Unkown
HY-107777 LLY-283 Inhibitor 99.22% Unkown
HY-138684 MRTX9768 Inhibitor 99.60% Unkown
HY-124131 DS-437 Inhibitor 98.00% Unkown
HY-148674 PRMT5-IN-25 Inhibitor 99.94% Unkown
HY-132309 BRD0639 Inhibitor 99.17% Unkown
HY-100025A HLCL-61 hydrochloride Inhibitor 99.95% Unkown
HY-139611C MRTX-1719 hydrochloride Inhibitor 99.22% Unkown
HY-128579 DW14800 Inhibitor 99.63% Unkown
HY-Q36691 PRMT5-IN-30 Inhibitor ≥95% Unkown
HY-126256 PRMT5-IN-1 Inhibitor / Unkown
HY-134883 PRMT5-IN-4 Inhibitor ≥99.0% Unkown
HY-141876 PRMT5-IN-14 Inhibitor / Unkown
HY-153421 PRMT5-IN-28 Inhibitor / Unkown
HY-139611B (S)-MRTX-1719 Inhibitor 97.07% Unkown
HY-158143 PRMT5-IN-34 Inhibitor / Unkown
HY-162230 PRMT5-IN-33 Inhibitor / Unkown
HY-P3822 PRMT5-IN-23 Inhibitor / Unkown
HY-132937 PRMT5-IN-9 Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-150081 PRMT5-IN-21 Inhibitor / Unkown
HY-149005 PRMT5-IN-19 Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt5 NCBI NCBI:10419