2. Gene
  3. Btk - Bruton tyrosine kinase Gene

Btk - Bruton tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 367901 | Gene type: protein coding

About Btk

Primary_assembly X: 97,722,802-97,761,853 reverse strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 206 orthologues, 32 paralogues and is associated with 36 phenotypes. Biased expression in Spleen (RPKM 217.2), Thymus (RPKM 46.2) and 3 other tissues.

Summary

Enables protein tyrosine kinase activity. Involved in several processes, including cellular response to molecule of Fungal origin; histamine secretion by mast cell; and positive regulation of hypersensitivity. Located in perinuclear region of cytoplasm. Used to study arthus reaction. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human Btk (Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Btk Products(1)

mRNA Protein Name
NM_001007798.2 NP_001007799.2 tyrosine-protein kinase BTK

Btk Protein Structure

PH_Btk

PH_Btk: cd01238 (5 - 167)

SH3_BTK

SH3_BTK: cd11906 (218 - 272)

SH2_Tec_Btk

SH2_Tec_Btk: cd10397 (275 - 379)

PTKc_Btk_Bmx

PTKc_Btk_Bmx: cd05113 (398 - 653)

  • 0
  • 200
  • 400
  • 600
  • 661 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase BTK

Bruton agammaglobulinemia tyrosine kinase

Related Agents

Approval
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10997 Ibrutinib Inhibitor 99.93% Yes
HY-17600 Acalabrutinib Inhibitor 99.88% Yes
HY-101474A Zanubrutinib Inhibitor 99.18% Yes
HY-129390 Orelabrutinib Inhibitor 99.90% Yes
HY-15771 Tirabrutinib Inhibitor 99.65% Yes
HY-15771A Tirabrutinib hydrochloride Inhibitor 99.43% Yes
HY-10997A Ibrutinib Racemate Inhibitor 95.13% Unkown
HY-101856 BMS-986142 Inhibitor 99.53% Yes
Clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Phase
HY-131328 Pirtobrutinib Inhibitor 99.88% Phase 3
HY-19834 Fenebrutinib Inhibitor 99.42% Phase 3
HY-128757 Remibrutinib Inhibitor 99.49% Phase 3
HY-109192 Tolebrutinib Inhibitor 99.79% Phase 3
HY-132842 Sunvozertinib Inhibitor 99.92% Phase 3
HY-112166 Rilzabrutinib Inhibitor 98.22% Phase 3
HY-19816A Avitinib maleate Inhibitor ≥98.0% Phase 3
HY-19816 Avitinib Inhibitor 99.90% Phase 3
HY-112215 Nemtabrutinib Inhibitor 98.64% Phase 2
HY-18012 Spebrutinib Inhibitor 99.62% Phase 2
HY-112161 Branebrutinib Inhibitor 99.82% Phase 2
HY-109078 Vecabrutinib Inhibitor 99.85% Phase 2
HY-109010 Poseltinib Inhibitor 98.08% Phase 2
HY-101215 Evobrutinib Inhibitor 98.60% Phase 2
HY-18012A Spebrutinib besylate Inhibitor / Phase 2
HY-139535 Luxeptinib Inhibitor 99.30% Phase 1
HY-153321 NX-5948 Degrader 99.33% Phase 1
HY-139984 BIIB091 Inhibitor 99.96% Phase 1
HY-132879 TAK-020 Inhibitor 99.93% Phase 1
Pre-clinical Phase
Bioactive Molecules (137)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153220 NX-2127 Inhibitor 99.72% Unkown
HY-100342 Ibrutinib-biotin Inhibitor 99.93% Unkown
HY-80003 QL47 Inhibitor 98.11% Unkown
HY-122562 MT-802 Inhibitor 98.94% Unkown
HY-80002 BMX-IN-1 Inhibitor 99.84% Unkown
HY-11999 CGI-1746 Inhibitor 96.54% Unkown
HY-18009 (Z)-LFM-A13 Inhibitor 99.97% Unkown
HY-133137 SJF620 Inhibitor 98.98% Unkown
HY-101474 (±)-Zanubrutinib Inhibitor 99.73% Unkown
HY-43521 Ibrutinib-MPEA 99.71% Unkown
HY-100335 PCI-33380 Inhibitor ≥98.0% Unkown
HY-15427 GDC-0834 Inhibitor 98.21% Unkown
HY-100338 CNX-500 Inhibitor 99.88% Unkown
HY-13943 CNX-774 Inhibitor 99.92% Unkown
HY-109143 Elsubrutinib Inhibitor ≥98.0% Unkown
HY-144288 BLK-IN-2 Inhibitor 98.72% Unkown
HY-18010 PCI 29732 Inhibitor 99.86% Unkown
HY-139481 TL-895 Inhibitor 99.76% Unkown
HY-130983 N-piperidine Ibrutinib hydrochloride Inhibitor 95.30% Unkown
HY-18018 RN486 Inhibitor 99.87% Unkown
HY-150023 BI-1622 Inhibitor 98.97% Unkown
HY-18951 ONO-4059 analog Inhibitor 99.74% Unkown
HY-15427A GDC-0834 Racemate 98.04% Unkown
HY-135334 ACP-5862 Inhibitor 98.41% Unkown
HY-15427B GDC-0834 (S-enantiomer) 98.03% Unkown
HY-131342 BIIB068 Inhibitor 99.69% Unkown
HY-132842A (S)-Sunvozertinib Inhibitor 99.14% Unkown
HY-101941 BTK IN-1 Inhibitor 98.01% Unkown
HY-101766 Btk inhibitor 2 Inhibitor 99.57% Unkown
HY-101474B (R)-Zanubrutinib 97.08% Unkown
HY-136531 XMU-MP-3 Inhibitor 98.27% Unkown
HY-153803 GBD-9 Inhibitor 99.76% Unkown
HY-153357 NRX-0492 Degrader 98.16% Unkown
HY-153110A Larotinib mesylate hydrate Inhibitor 98.66% Unkown
HY-101793 BMS-935177 Inhibitor 99.11% Unkown
HY-100659 Dihydrodiol-Ibrutinib Inhibitor 99.92% Unkown
HY-124645 QL-X-138 Inhibitor 99.77% Unkown
HY-10997S Ibrutinib-d5 Inhibitor 98.08% Unkown
HY-131705 BTK inhibitor 17 Inhibitor 98.98% Unkown
HY-13036B IBT6A hydrochloride Inhibitor 99.72% Unkown
HY-17600S Acalabrutinib-d4 Inhibitor 99.50% Unkown
HY-125997 BTK inhibitor 10 Inhibitor 99.66% Unkown
HY-132808 Atuzabrutinib Inhibitor 98.01% Unkown
HY-133137A SJF620 hydrochloride Inhibitor 99.28% Unkown
HY-78727 Ibrutinib deacryloylpiperidine Inhibitor 99.96% Unkown
HY-101474S Zanubrutinib-d5 Inhibitor ≥98.0% Unkown
HY-110013 Terreic acid Inhibitor / Unkown
HY-160246 QL47B Inhibitor / Unkown
HY-131328A (R)-Pirtobrutinib 99.78% Unkown
HY-110002 LFM-A13 Inhibitor / Unkown
HY-109143B (R)-Elsubrutinib Inhibitor ≥98.0% Unkown
HY-13036A IBT6A Inhibitor 99.43% Unkown
HY-13036 (Rac)-IBT6A Inhibitor 98.18% Unkown
HY-160246A QL47B TFA Inhibitor / Unkown
HY-151808 JS25 Inhibitor 98.37% Unkown
HY-132196 BTK inhibitor 18 Inhibitor / Unkown
HY-130255 BTK inhibitor 13 Inhibitor / Unkown
HY-115876 BTK-IN-5 Inhibitor / Unkown
HY-145373 BMS-986143 Inhibitor / Unkown
HY-137438 Edralbrutinib Inhibitor / Unkown
HY-102036 G-744 Inhibitor / Unkown
HY-153245 JNJ-64264681 Inhibitor / Unkown
HY-156604 Cinsebrutinib Inhibitor / Unkown
HY-101521 CHMFL-BTK-01 Inhibitor / Unkown
HY-149051 BGB-8035 Inhibitor / Unkown
HY-153110 Larotinib Inhibitor / Unkown
HY-117900 PF-06250112 Inhibitor / Unkown
HY-147584 BTK-IN-14 Inhibitor / Unkown
HY-122830 DD-03-171 Degrader / Unkown
HY-149391 PROTAC BTK Degrader-6 Degrader / Unkown
HY-148832 BTK-IN-20 Inhibitor / Unkown
HY-156553 BTK-IN-27 Inhibitor / Unkown
HY-147581 BTK-IN-11 Inhibitor / Unkown
HY-122828 PROTAC BTK Degrader-2 Degrader / Unkown
HY-156746 DBt-10 Degrader / Unkown
HY-143718 JAK3/BTK-IN-3 Inhibitor / Unkown
HY-148585 BTK-IN-22 Inhibitor / Unkown
HY-163183 JAK3/BTK-IN-7 Inhibitor / Unkown
HY-163295 BTK degrader-1 Degrader / Unkown
HY-152201 BTK-IN-18 Inhibitor / Unkown
HY-147943 PROTAC BTK Degrader-1 / Unkown
HY-160219S BTK-IN-33 Inhibitor / Unkown
HY-155072 PROTAC BTK Degrader-5 Degrader / Unkown
HY-153951S BTK-IN-26 Inhibitor / Unkown
HY-162407 I-As-1 Inhibitor / Unkown
HY-162257 BTK-IN-34 Inhibitor / Unkown
HY-151920 BTK-IN-17 Inhibitor / Unkown
HY-144283 BLK-IN-1 Inhibitor / Unkown
HY-142621 BCPyr Inhibitor / Unkown
HY-147580 BTK-IN-10 Inhibitor / Unkown
HY-143717 JAK3/BTK-IN-2 Inhibitor / Unkown
HY-139881 BTK inhibitor 19 Inhibitor / Unkown
HY-157159 BTK-IN-28 Inhibitor / Unkown
HY-143900 BTK-IN-7 Inhibitor / Unkown
HY-156969 Topoisomerase I inhibitor 11 / Unkown
HY-117900A (Rac)-PF-06250112 / Unkown
HY-147741 DPPY Inhibitor / Unkown
HY-145884 BTK-IN-8 Inhibitor / Unkown
HY-115944 BTK-IN-9 Inhibitor / Unkown
HY-153220A (R)-NX-2127 Degrader / Unkown
HY-154860 PTD10 Degrader / Unkown
HY-144170 RET-IN-14 Inhibitor / Unkown
HY-151961 RSH-7 Inhibitor 99.07% Unkown
HY-150752 BTK-IN-15 Inhibitor / Unkown
HY-123117 VA5 Inhibitor / Unkown
HY-143720 JAK3/BTK-IN-5 Inhibitor / Unkown
HY-148594 BTK-IN-23 Inhibitor / Unkown
HY-157763 PROTAC BTK Degrader-8 Degrader / Unkown
HY-135334S ACP-5862-d4 Inhibitor / Unkown
HY-147784 HZ-A-005 Inhibitor / Unkown
HY-142932 BTK-IN-6 Inhibitor / Unkown
HY-162081 BTK-IN-32 Inhibitor / Unkown
HY-150885 BTK ligand 1 Degrader / Unkown
HY-143730 BTK inhibitor 20 Inhibitor / Unkown
HY-147754 JAK3/BTK-IN-6 Inhibitor / Unkown
HY-153705 BTK-IN-25 Inhibitor / Unkown
HY-143719 JAK3/BTK-IN-4 Inhibitor / Unkown
HY-147582 BTK-IN-12 Inhibitor / Unkown
HY-143901 EGFR-IN-40 Inhibitor / Unkown
HY-110113 CTA056 Inhibitor / Unkown
HY-101474BS (R)-Zanubrutinib-d5 / Unkown
HY-152212 BTK-IN-19 Inhibitor / Unkown
HY-151211 BTK-IN-16 Inhibitor / Unkown
HY-153536 PROTAC BTK Degrader-3 Inhibitor / Unkown
HY-15805 KIN-8194 Inhibitor / Unkown
HY-101522 CHMFL-EGFR-202 Inhibitor 99.75% Unkown
HY-100659S Dihydrodiol-Ibrutinib-d5 Inhibitor / Unkown
HY-141689 BTK-IN-3 Inhibitor / Unkown
HY-162280 PROTAC BTK Degrader-9 Degrader / Unkown
HY-136113 Ibrutinib dimer Inhibitor / Unkown
HY-143716 JAK3/BTK-IN-1 Inhibitor / Unkown
HY-13036C (Rac)-IBT6A hydrochloride Inhibitor / Unkown
HY-160142 UBX-382 Degrader / Unkown
HY-160168 BTK-IN-31 Inhibitor / Unkown
HY-160167 BTK-IN-30 Inhibitor / Unkown
HY-128403 BTK inhibitor 8 Inhibitor / Unkown
HY-160141 BTK-IN-29 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Btk NCBI NCBI:695