KLRC3 - killer cell lectin like receptor C3 Gene

Homo sapiens

Also known as NKG2E; NKG2-E

Gene ID: 3823 | Gene type: protein coding

About KLRC3

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,412,315-10,420,595 (from NCBI)

This gene has 2 transcripts (splice variants), 456 orthologues and 23 paralogues. Biased expression in brain (RPKM 5.1), spleen (RPKM 3.6) and 8 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

KLRC3 Products(2)

mRNA	Protein	Name
NM_002261.3	NP_002252.2	NKG2-E type II integral membrane protein isoform E
NM_007333.2	NP_031359.2	NKG2-E type II integral membrane protein isoform H

KLRC3 Protein Structure

Lectin_C

0
100
200
240 a.a.

Protein Preferred Names

Protein Names

NKG2-E type II integral membrane protein

NK cell receptor E

Recombinant KLRC3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79418	NKG2E Protein, Human (HEK293, hFc)	Q07444-1 (P100-K330)	≥95%

Related Diseases

Diseases

Alias

Nasal Type Extranodal Nk/T-Cell Lymphoma

Extranodal Nasal Nk/T Cell Lymphoma	Angiocentric T-Cell Lymphoma
Lethal Midline Granuloma	Nk/T-Cell Lymphoma
Nktcl	Nasal T/Natural Killer-Cell Lymphoma
Granuloma, Lethal Midline	Nasal And Nasal-Type Nk/T-Cell Lymphoma

Glioblastoma Mesenchymal Subtype

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07393	KLRC3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KLRC3	MGD	MGI:1929720
Rattus norvegicus	KLRC3	RGD	RGD:1560637

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