2. Gene
  3. LRP3 - LDL receptor related protein 3 Gene

LRP3 - LDL receptor related protein 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 4037 | Gene type: protein coding

About LRP3

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:33,194,330-33,208,864 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues and 14 paralogues. Ubiquitous expression in ovary (RPKM 23.4), fat (RPKM 17.1) and 24 other tissues.

Summary

Involved in negative regulation of fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be located in clathrin-coated pit. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRP3 Products(1)

mRNA Protein Name
NM_002333.4 NP_002324.2 low-density lipoprotein receptor-related protein 3 precursor

LRP3 Protein Structure

CUB

CUB: CUB domain (43 - 156)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (165 - 200)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (212 - 249)

CUB

CUB: CUB domain (254 - 362)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (455 - 489)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 3

105 kDa low-density lipoprotein receptor-related protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103715 NLRP3 modulators 1 Modulator / Unkown
HY-RS07798 LRP3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LRP3 VGNC VGNC:68088
Macaca mulatta LRP3 VGNC VGNC:74444
Rattus norvegicus LRP3 RGD RGD:619729
Canis familiaris LRP3 VGNC VGNC:42776
Mus musculus LRP3 MGD MGI:3584516
Bos taurus LRP3 VGNC VGNC:30991
Others LRP3 NCBI