LTK - leukocyte receptor tyrosine kinase Gene

Homo sapiens

Also known as TYK1

Gene ID: 4058 | Gene type: protein coding

About LTK

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,503,637-41,513,827 (from NCBI)

This gene has 6 transcripts (splice variants), 62 orthologues and 53 paralogues. Broad expression in duodenum (RPKM 6.4), lung (RPKM 6.1) and 15 other tissues.

Summary

The protein encoded by this gene is a member of the ros/Insulin Receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

LTK Products(3)

mRNA	Protein	Name
NM_001135685.2	NP_001129157.1	leukocyte tyrosine kinase receptor isoform 3 precursor
NM_002344.6	NP_002335.2	leukocyte tyrosine kinase receptor isoform 1 precursor
NM_206961.4	NP_996844.1	leukocyte tyrosine kinase receptor isoform 2 precursor

LTK Protein Structure

Gly_rich

Pkinase_Tyr

0
200
400
600
800
864 a.a.

Protein Preferred Names

Protein Names

leukocyte tyrosine kinase receptor

protein tyrosine kinase 1

Related Diseases

Diseases

Alias

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Her2-Receptor Positive Breast Cancer

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156467A	ALK-IN-27 TFA	Inhibitor	/	Unkown
HY-156467	ALK-IN-27	Inhibitor	98.01%	Unkown
HY-131909	CJ-2360	Inhibitor	/	Unkown
HY-108263B	(R)-3-Hydroxy Midostaurin	Inhibitor	/	Unkown
HY-110347	Mps1-IN-1 dihydrochloride	Inhibitor	/	Unkown
HY-145256	GABAA receptor agent 4	Antagonist	/	Unkown
HY-145257	GABAA receptor agent 5	Antagonist	/	Unkown
HY-155516	KV1.3-IN-1	Inhibitor	/	Unkown
HY-RS07884	LTK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LTK	VGNC	VGNC:84372
Mus musculus	LTK	MGD	MGI:96840
Rattus norvegicus	LTK	RGD	RGD:1309323
Others	LTK	NCBI

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