MAGEB2 - MAGE family member B2 Gene

Homo sapiens

Also known as DAM6; CT3.2; MAGE-XP-2

Gene ID: 4113 | Gene type: protein coding

About MAGEB2

Cytogenetic location: Xp21.2 Genomic coordinates (GRCh38): X:30,215,563-30,220,089 (from NCBI)

This gene has 1 transcript (splice variant), 280 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 20.5).

Summary

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]

MAGEB2 Products(1)

mRNA	Protein	Name
NM_002364.5	NP_002355.2	melanoma-associated antigen B2

MAGEB2 Protein Structure

MAGE_N

MAGE

0
100
200
300
319 a.a.

Protein Preferred Names

Protein Names

melanoma-associated antigen B2

DSS/AHC critical interval MAGE superfamily 6

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07971	MAGEB2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAGEB2	RGD	RGD:1560904
Macaca mulatta	MAGEB2	VGNC	VGNC:74477
Mus musculus	MAGEB2	MGD	MGI:2148568

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